UniProt Accession

 CSN6_MOUSE; O88545 

Genbank Protein ID

 AF071315; BC004664; BC014286 

Genbank Nucleotide ID

 AAC33902.1; AAH04664.1; AAH14286.1 

Protein Name

 COP9 signalosome complex subunit 6 

Protein Synonyms/Alias

 SGN6; Signalosome subunit 6; JAB1-containing signalosome subunit 6 

Gene Name

 Cops6 

Gene Synonyms/Alias

 Csn6 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
99	EEKIIIDKEYYYTKE	ubiquitination	[1]
240	KLILEYVKASEAGEV	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Has some glucocorticoid receptor- responsive activity (By similarity). Stabilizes RFWD2/COP1 through reducing RFWD2 auto-ubiquitination and decelerating RFWD2 turnover rate, hence regulates the ubiquitination of RFWD2 targets, including SFN (By similarity). 

Sequence Annotation

 DOMAIN 36 145 MPN.  

Keyword

 Complete proteome; Cytoplasm; Nucleus; Reference proteome; Signalosome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 324 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0008180; C:signalosome; IDA:MGI.
 GO:0010388; P:cullin deneddylation; IEA:Compara. 

Interpro

 IPR000555; JAB1_Mov34_MPN_PAD1.
 IPR024969; Rpn11/EIF3F_C. 

Pfam

 PF01398; JAB
 PF13012; MitMem_reg 

SMART

 SM00232; JAB_MPN 

PROSITE

  

PRINTS