UniProt Accession

 PAF15_RAT; Q6RIA2 

Genbank Protein ID

 AY496944 

Genbank Nucleotide ID

 AAR90859.1 

Protein Name

 PCNA-associated factor 

Protein Synonyms/Alias

 HCV NS5A-transactivated protein 9 homolog; PCNA-associated factor of 15 kDa; PAF15; p15PAF 

Gene Name

 Paf 

Gene Synonyms/Alias

 Ns5atp9 

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
92	AGSSGLGKAKRKACP	acetylation	[1]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 

Functional Description

 PCNA-binding protein that acts as a regulator of DNA repair during DNA replication. Following DNA damage, the interaction with PCNA is disrupted, facilitating the interaction between monoubiquitinated PCNA and the translesion DNA synthesis DNA polymerase eta (POLH) at stalled replisomes, facilitating the bypass of replication-fork-blocking lesions. Also acts as a regulator of centrosome number (By similarity). 

Sequence Annotation

 MOTIF 23 34 D-box.
 MOTIF 61 71 PIP-box.
 MOTIF 77 79 KEN box.
 MOTIF 84 96 Initiation motif.
 MOD_RES 71 71 Phosphoserine (By similarity).
 CROSSLNK 15 15 Glycyl lysine isopeptide (Lys-Gly)
 CROSSLNK 24 24 Glycyl lysine isopeptide (Lys-Gly)  

Keyword

 Complete proteome; Cytoplasm; DNA damage; DNA repair; Isopeptide bond; Nucleus; Phosphoprotein; Reference proteome; Ubl conjugation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 110 AA 

Protein Sequence

Gene Ontology

 GO:0005634; C:nucleus; ISS:UniProtKB.
 GO:0048471; C:perinuclear region of cytoplasm; ISS:UniProtKB.
 GO:0003682; F:chromatin binding; ISS:UniProtKB.
 GO:0051297; P:centrosome organization; ISS:UniProtKB.
 GO:0006260; P:DNA replication; ISS:UniProtKB.
 GO:0051726; P:regulation of cell cycle; ISS:UniProtKB.
 GO:0009411; P:response to UV; ISS:UniProtKB.
 GO:0019985; P:translesion synthesis; ISS:UniProtKB. 

Interpro

  

Pfam

  

SMART

  

PROSITE

  

PRINTS