CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-018293
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Pentatricopeptide repeat-containing protein 2, mitochondrial 
Protein Synonyms/Alias
  
Gene Name
 PTCD2 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
112RDHVELAKNVIYRYHubiquitination[1, 2]
123YRYHAENKNFTLGEYubiquitination[1, 2]
Reference
 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 
Functional Description
 Involved in mitochondrial RNA maturation and mitochondrial respiratory chain function (By similarity). 
Sequence Annotation
 REPEAT 166 200 PPR.  
Keyword
 Complete proteome; Mitochondrion; mRNA processing; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 388 AA 
Protein Sequence
MVRDSMAAAF RPSNRVLLQA LQILVYPGVG GSGSVSCRCP LGAKRYLLTD NVVKLKEFQQ 60
KKVAVACNLS GTKETYFRNL KKKLTQNKLI LKGELITLLH LCESRDHVEL AKNVIYRYHA 120
ENKNFTLGEY KFGPLFVRLC YELDLEESAV ELMKDQHLRG FFSDSTSFNI LMDMLFIKGK 180
YKSALQVLIE MKNQDVKFTK DTYVLAFAIC YKLNSPESFK ICTTLREEAL LKGEILSRRA 240
SCFAVALALN QNEMAKAVSI FSQIMNPESI ACINLNIIIH IQSNMLENLI KTLKNAAEGN 300
LSKFVKRHVF SEEVLAKVRE KVKDVPALVA KFDEIYGTLH ITGQVTTDSL DAVLCHTPRD 360
RKSHTLLLNK RMVSRRTFQP LSQSLLAE 388 
Gene Ontology
 GO:0005739; C:mitochondrion; IDA:UniProtKB.
 GO:0001822; P:kidney development; IEA:Compara.
 GO:0001889; P:liver development; IEA:Compara.
 GO:0007005; P:mitochondrion organization; IEA:Compara.
 GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.
 GO:0048747; P:muscle fiber development; IEA:Compara.
 GO:0050684; P:regulation of mRNA processing; ISS:UniProtKB.
 GO:0055010; P:ventricular cardiac muscle tissue morphogenesis; IEA:Compara. 
Interpro
 IPR002885; Pentatricopeptide_repeat.
 IPR019266; Ribosomal_S27_mit. 
Pfam
 PF10037; MRP-S27 
SMART
  
PROSITE
 PS51375; PPR 
PRINTS