CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-034194
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A 
Protein Synonyms/Alias
  
Gene Name
 Pde10a 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
23FQVDHKNKELYSDLFubiquitination[1]
54EIRFSIEKGIAGQVAubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Hydrolase; Metal-binding; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 512 AA 
Protein Sequence
MIYAKNLVNA DRCALFQVDH KNKELYSDLF DIGEEKEGKP IFKKTKEIRF SIEKGIAGQV 60
ARTGEVLNIP DAYADPRFNR EVDLYTGYTT RNILCMPIVS RGSVIGVVQM VNKISGSAFS 120
KTDENNFKMF AVFCALALHC ANMYHRIRHS ECIYRVTMEK LSYHSICTSE EWQGLMRFNL 180
PARICRDIEL FHFDIGPFEN MWPGIFVYMI HRSCGTSCFE LEKLCRFIMS VKKNYRRVPY 240
HNWKHAVTVA HCMYAILQNN NGLFTDLERK GLLIACLCHD LDHRGFSNSY LQKFDHPLAA 300
LYSTSTMEQH HFSQTVSILQ LEGHNIFSTL SSSEYEQVLE IIRKAIIATD LALYFGNRKQ 360
LEEMYQTGSL NLHNQSHRDR VIGLMMTACD LCSVTKLWPV TKLTANDIYA EFWAEGDEMK 420
KLGIQPIPMM DRDKRDEVPQ GQLGFYNAVA IPCYTTLTQI LPPTEPLLKA CRDNLNQWEK 480
VIRGEETAMW ISGPGPAPSK STPEKLNVKV ED 512 
Gene Ontology
 GO:0004114; F:3',5'-cyclic-nucleotide phosphodiesterase activity; IDA:MGI.
 GO:0004118; F:cGMP-stimulated cyclic-nucleotide phosphodiesterase activity; IEA:Compara.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0043949; P:regulation of cAMP-mediated signaling; IMP:MGI.
 GO:0010738; P:regulation of protein kinase A signaling cascade; IMP:MGI.
 GO:0007165; P:signal transduction; IEA:InterPro. 
Interpro
 IPR003018; GAF.
 IPR003607; HD/PDEase_dom.
 IPR023088; PDEase.
 IPR002073; PDEase_catalytic_dom.
 IPR023174; PDEase_CS. 
Pfam
 PF01590; GAF
 PF00233; PDEase_I 
SMART
 SM00065; GAF
 SM00471; HDc 
PROSITE
 PS00126; PDEASE_I 
PRINTS
 PR00387; PDIESTERASE1.