CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-024049
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Solute carrier family 22 member 5 
Protein Synonyms/Alias
 High-affinity sodium-dependent carnitine cotransporter; Organic cation/carnitine transporter 2 
Gene Name
 Slc22a5 
Gene Synonyms/Alias
 Octn2 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
531MLRVKGIKQWQIQSQubiquitination[1]
543QSQTRMQKDGEESPTubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 Sodium-ion dependent, high affinity carnitine transporter. Involved in the active cellular uptake of carnitine. Transports one sodium ion with one molecule of carnitine. Also transports organic cations such as tetraethylammonium (TEA) without the involvement of sodium. Also relative uptake activity ratio of carnitine to TEA is 11.3. 
Sequence Annotation
 NP_BIND 218 225 ATP (Potential).
 MOD_RES 486 486 Phosphotyrosine (By similarity).
 CARBOHYD 57 57 N-linked (GlcNAc...) (Potential).
 CARBOHYD 64 64 N-linked (GlcNAc...) (Potential).
 CARBOHYD 91 91 N-linked (GlcNAc...) (Potential).  
Keyword
 ATP-binding; Cell membrane; Complete proteome; Disease mutation; Glycoprotein; Ion transport; Membrane; Nucleotide-binding; Phosphoprotein; Reference proteome; Sodium; Sodium transport; Symport; Transmembrane; Transmembrane helix; Transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 557 AA 
Protein Sequence
MRDYDEVTAF LGEWGPFQRL IFFLLSASII PNGFNGMSIV FLAGTPEHRC LVPHTVNLSS 60
AWRNHSIPLE TKDGRQVPQK CRRYRLATIA NFSELGLEPG RDVDLEQLEQ ESCLDGWEYD 120
KDVFLSTIVT EWDLVCKDDW KAPLTTSLFF VGVLMGSFIS GQLSDRFGRK NVLFLTMGMQ 180
TGFSFLQVFS VNFEMFTVLF VLVGMGQISN YVAAFVLGTE ILSKSIRIIF ATLGVCIFYA 240
FGFMVLPLFA YFIRDWRMLL LALTVPGVLC GALWWFIPES PRWLISQGRI KEAEVIIRKA 300
AKINGIVAPS TIFDPSELQD LNSTKPQLHH IYDLIRTRNI RVITIMSIIL WLTISVGYFG 360
LSLDTPNLHG DIYVNCFLLA AVEVPAYVLA WLLLQYLPRR YSISAALFLG GSVLLFMQLV 420
PSELFYLSTA LVMVGKFGIT SAYSMVYVYT AELYPTVVRN MGVGVSSTAS RLGSILSPYF 480
VYLGAYDRFL PYILMGSLTI LTAILTLFFP ESFGVPLPDT IDQMLRVKGI KQWQIQSQTR 540
MQKDGEESPT VLKSTAF 557 
Gene Ontology
 GO:0016324; C:apical plasma membrane; IEA:UniProtKB-SubCell.
 GO:0031526; C:brush border membrane; IDA:BHF-UCL.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0015226; F:carnitine transmembrane transporter activity; IDA:MGI.
 GO:0015293; F:symporter activity; IEA:UniProtKB-KW.
 GO:0007512; P:adult heart development; IMP:MGI.
 GO:0009437; P:carnitine metabolic process; IMP:MGI.
 GO:0007626; P:locomotory behavior; IMP:MGI.
 GO:0007005; P:mitochondrion organization; IMP:MGI.
 GO:0048608; P:reproductive structure development; IMP:MGI.
 GO:0006814; P:sodium ion transport; IEA:UniProtKB-KW. 
Interpro
 IPR020846; MFS_dom.
 IPR016196; MFS_dom_general_subst_transpt.
 IPR004749; Orgcat_transp.
 IPR005828; Sub_transporter.
 IPR005829; Sugar_transporter_CS. 
Pfam
 PF00083; Sugar_tr 
SMART
  
PROSITE
 PS50850; MFS
 PS00216; SUGAR_TRANSPORT_1 
PRINTS