| Tag | Content |
|---|
| CPLM ID | CPLM-008248 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Transcription initiation factor TFIID subunit 4 |
Protein Synonyms/Alias | MPT-1; TAF suppressor gene 2 protein; TAFII-48; TBP-associated factor 4; TBP-associated factor 48 kDa |
Gene Name | TAF4 |
Gene Synonyms/Alias | MPT1; TAF48; TSG2; YMR005W; YM8270.07 |
Created Date | July 27, 2013 |
Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
NCBI Taxa ID | 559292 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 21 | VSASDTPKYQHTVPE | acetylation | [1] | | 335 | LGAKSSGKVASDITA | acetylation | [1] |
|
Reference | [1] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae. Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C. Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [ PMID: 22865919] |
Functional Description | Functions as a component of the DNA-binding general transcription factor complex TFIID. Binding of TFIID to a promoter (with or without TATA element) is the initial step in pre- initiation complex (PIC) formation. TFIID plays a key role in the regulation of gene expression by RNA polymerase II through different activities such as transcription activator interaction, core promoter recognition and selectivity, TFIIA and TFIIB interaction, chromatin modification (histone acetylation by TAF1), facilitation of DNA opening and initiation of transcription. |
Sequence Annotation | DOMAIN 193 261 Histone-fold.
MOD_RES 36 36 Phosphoserine.
MOD_RES 49 49 Phosphoserine.
MOD_RES 80 80 Phosphoserine. |
Keyword | Coiled coil; Complete proteome; Nucleus; Phosphoprotein; Reference proteome; Transcription; Transcription regulation. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 388 AA |
Protein Sequence | MANSPKKPSD GTGVSASDTP KYQHTVPETK PAFNLSPGKA SELSHSLPSP SQIKSTAHVS 60
STHNDAAGNT DDSVLPKNVS PTTNLRVESN GDTNNMFSSP AGLALPKKDD KKKNKGTSKA 120
DSKDGKASNS SGQNAQQQSD PNKMQDVLFS AGIDVREEEA LLNSSINASK SQVQTNNVKI 180
PNHLPFLHPE QVSNYMRKVG KEQNFNLTPT KNPEILDMMS SACENYMRDI LTNAIVISRH 240
RRKAVKINSG RRSEVSAALR AIALIQKKEE ERRVKKRIAL GLEKEDYENK IDSEETLHRA 300
SNVTAGLRAG SKKQYGWLTS SVNKPTSLGA KSSGKVASDI TARGESGLKF REAREEPGIV 360
MRDLLFALEN RRNSVQTIIS KGYAKIRD 388 |
Gene Ontology | GO:0005669; C:transcription factor TFIID complex; IDA:SGD. GO:0003682; F:chromatin binding; IDA:SGD. GO:0003677; F:DNA binding; IDA:UniProtKB. GO:0001102; F:RNA polymerase II activating transcription factor binding; IDA:SGD. GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW. GO:0051123; P:RNA polymerase II transcriptional preinitiation complex assembly; IC:SGD. |
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