CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-004588
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 4-aminobutyrate aminotransferase 
Protein Synonyms/Alias
 GABA aminotransferase; GABA-AT; Gamma-amino-N-butyrate transaminase; GABA transaminase 
Gene Name
 UGA1 
Gene Synonyms/Alias
 YGR019W 
Created Date
 July 27, 2013 
Organism
 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 
NCBI Taxa ID
 559292 
Lysine Modification
Position
Peptide
Type
References
344DPKFIPNKPYRQFNTacetylation[1]
Reference
 [1] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae.
 Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C.
 Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [PMID: 22865919] 
Functional Description
 Required for the degradation of gamma-aminobutyric acid (GABA), which is important for utilization of GABA as nitrogen source and for oxidative stress tolerance. Deaminates GABA to succinate semialdehyde, which in turn is converted to succinate by the succinate-semialdehyde dehydrogenase UGA2. Cannot transaminate beta-alanine (BAL). 
Sequence Annotation
 MOD_RES 326 326 N6-(pyridoxal phosphate)lysine (By  
Keyword
 Aminotransferase; Complete proteome; Cytoplasm; Pyridoxal phosphate; Reference proteome; Transferase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 471 AA 
Protein Sequence
MSICEQYYPE EPTKPTVKTE SIPGPESQKQ LKELGEVFDT RPAYFLADYE KSLGNYITDV 60
DGNTYLDLYA QISSIALGYN NPALIKAAQS PEMIRALVDR PALGNFPSKD LDKILKQILK 120
SAPKGQDHVW SGLSGADANE LAFKAAFIYY RAKQRGYDAD FSEKENLSVM DNDAPGAPHL 180
AVLSFKRAFH GRLFASGSTT CSKPIHKLDF PAFHWPHAEY PSYQYPLDEN SDANRKEDDH 240
CLAIVEELIK TWSIPVAALI IEPIQSEGGD NHASKYFLQK LRDITLKYNV VYIIDEVQTG 300
VGATGKLWCH EYADIQPPVD LVTFSKKFQS AGYFFHDPKF IPNKPYRQFN TWCGEPARMI 360
IAGAIGQEIS DKKLTEQCSR VGDYLFKKLE GLQKKYPENF QNLRGKGRGT FIAWDLPTGE 420
KRDLLLKKLK LNGCNVGGCA VHAVRLRPSL TFEEKHADIF IEALAKSVNE L 471 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0005622; C:intracellular; IC:SGD.
 GO:0003867; F:4-aminobutyrate transaminase activity; IMP:SGD.
 GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
 GO:0009450; P:gamma-aminobutyric acid catabolic process; IMP:SGD.
 GO:0019740; P:nitrogen utilization; TAS:SGD. 
Interpro
 IPR004631; 4NH2But_aminotransferase_euk.
 IPR005814; Aminotrans_3.
 IPR015424; PyrdxlP-dep_Trfase.
 IPR015421; PyrdxlP-dep_Trfase_major_sub1.
 IPR015422; PyrdxlP-dep_Trfase_major_sub2. 
Pfam
 PF00202; Aminotran_3 
SMART
  
PROSITE
 PS00600; AA_TRANSFER_CLASS_3 
PRINTS