CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-000195
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Transcription initiation factor IIA subunit 1 
Protein Synonyms/Alias
 General transcription factor IIA subunit 1; Transcription initiation factor IIA alpha chain; TFIIA p35 subunit; Transcription initiation factor IIA beta chain; TFIIA p19 subunit 
Gene Name
 Gtf2a1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
12ANTNTVPKLYRSVIEacetylation[1]
351HRSKNKWKFHLKDGIacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 
Functional Description
 TFIIA is a component of the transcription machinery of RNA polymerase II and plays an important role in transcriptional activation. TFIIA in a complex with TBP mediates transcriptional activity (By similarity). 
Sequence Annotation
 MOD_RES 2 2 N-acetylalanine (By similarity).
 MOD_RES 281 281 Phosphoserine; by TAF1 (By similarity).
 MOD_RES 282 282 Phosphoserine; by TAF1 (By similarity).
 MOD_RES 317 317 Phosphoserine; by TAF1 (By similarity).
 MOD_RES 322 322 Phosphoserine; by TAF1 (By similarity).  
Keyword
 Acetylation; Complete proteome; Nucleus; Phosphoprotein; Reference proteome; Transcription; Transcription regulation. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 377 AA 
Protein Sequence
MANSANTNTV PKLYRSVIED VINDVRDIFL DDGVDEQVLM ELKTLWENKL MQSRAVDGFH 60
SEEQQLLLQV QQQHQPQQQQ HHHHHHHQQA QPQQTVPQQA QTQQVLIPAS QQATAPQVIV 120
PDSKLIQHMN ASSITSAAAT AATLALPAGV TPVQQILTNS GQLLQVVRAA NGAQYIFQPQ 180
QSVVLQQQVI PQMQPGGVQA PVIQQVLAPL PGGISPQTGV IIQPQQILFT GNKTQVIPTT 240
VAAPTPAQAQ IPAAGQQQPQ AQPAQQQAPL VLQVDGTGDT SSEEDEDEEE DYDDDEEEDK 300
EKDGAEDGQV EEEPLNSEDD VSDEEGQELF DTENVVVCQY DKIHRSKNKW KFHLKDGIMN 360
LNGRDYIFSK AIGDAEW 377 
Gene Ontology
 GO:0005672; C:transcription factor TFIIA complex; IEA:InterPro.
 GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.
 GO:0006367; P:transcription initiation from RNA polymerase II promoter; IEA:InterPro. 
Interpro
 IPR009083; TFIIA_a-hlx.
 IPR004855; TFIIA_asu/bsu.
 IPR013028; TFIIA_asu_N.
 IPR009088; TFIIA_b-brl. 
Pfam
 PF03153; TFIIA 
SMART
  
PROSITE
  
PRINTS