CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-019942
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Periodic tryptophan protein 1 homolog 
Protein Synonyms/Alias
  
Gene Name
 Pwp1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
300RLTAHTDKVQTLQFHubiquitination[1]
407LVTASADKFVKIWDIacetylation[2]
481RLVIGGTKGLSVSGPubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441] 
Functional Description
 May play an important role in cell growth and/or transcription (By similarity). 
Sequence Annotation
 REPEAT 185 229 WD 1.
 REPEAT 253 293 WD 2.
 REPEAT 296 336 WD 3.
 REPEAT 382 422 WD 4.
 REPEAT 427 467 WD 5.
 MOD_RES 49 49 Phosphoserine.
 MOD_RES 58 58 Phosphoserine (By similarity).
 MOD_RES 85 85 Phosphothreonine (By similarity).
 MOD_RES 493 493 Phosphoserine.  
Keyword
 Complete proteome; Nucleus; Phosphoprotein; Reference proteome; Repeat; WD repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 501 AA 
Protein Sequence
MNRSRQVTCV AWVRRGVAKE TPDKVELSKE EVNRLIAEAK GKLQEEGGSE EEEAGNPSED 60
GMQSGPTQAP PRESLEDGDP QDDRTLDDDE LAGYDLDNYD EEDNPDAETI GESLLGLTVY 120
GSNDQDPYVT LKDTEQYEHE DFLIKPTDNL IVCGRAEQEQ CNLEVHVYNQ EEESFYVHHD 180
ILLSAYPLSV EWLNFDPSPD ASTGNYIAVG NMTPVIEVWD LDIVDSLEPV FTLGSKLSKK 240
KKKKGKKSSS AEGHTDAVLD LSWNKTVRNV LASASADSTV VLWDLSVGKS VARLTAHTDK 300
VQTLQFHPFE AQTLISGSYD KSVALYDCRD PSQNHRQWRF SGQIERVTWN HFSPCHFLAS 360
TDDGFVYNLD ARSDKPIFTL NAHNDEISGL DLSSQIKGCL VTASADKFVK IWDILGDRPS 420
LIHSRDMKMG VLFCSSCCPD LPFVYAFGGQ KEGLRVWDIS TVSSVNEAFG RRERLVIGGT 480
KGLSVSGPCG SRSPQQTPME S 501 
Gene Ontology
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. 
Interpro
 IPR020472; G-protein_beta_WD-40_rep.
 IPR015943; WD40/YVTN_repeat-like_dom.
 IPR001680; WD40_repeat.
 IPR019775; WD40_repeat_CS.
 IPR017986; WD40_repeat_dom. 
Pfam
 PF00400; WD40 
SMART
 SM00320; WD40 
PROSITE
 PS00678; WD_REPEATS_1
 PS50082; WD_REPEATS_2
 PS50294; WD_REPEATS_REGION 
PRINTS
 PR00320; GPROTEINBRPT.