UniProt Accession

 TERF2_MOUSE; O35144; D3YVG5; Q80VE2; Q8BQJ9 

Genbank Protein ID

 AK049507; AC123868; BC046284; AF003000 

Genbank Nucleotide ID

 BAC33784.1; AAH46284.1; AAB81136.1 

Protein Name

 Telomeric repeat-binding factor 2 

Protein Synonyms/Alias

 TTAGGG repeat-binding factor 2; Telomeric DNA-binding protein 

Gene Name

 Terf2 

Gene Synonyms/Alias

 Trf2 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
337	RTLKAAFKALSTAQD	acetylation	[1]

Reference

 [1] p300-mediated acetylation of TRF2 is required for maintaining functional telomeres.
 Her YR, Chung IK.
 Nucleic Acids Res. 2013 Feb 1;41(4):2267-83. [PMID: 23307557] 

Functional Description

 Binds the telomeric double-stranded 5'-TTAGGG-3' repeat and plays a central role in telomere maintenance and protection against end-to-end fusion of chromosomes. In addition to its telomeric DNA-binding role, required to recruit a number of factors and enzymes required for telomere protection, including the shelterin complex, TERF2IP/RAP1 and DCLRE1B/Apollo. Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded 5'-TTAGGG-3' repeats added by telomerase and protects chromosome ends; without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways. Together with DCLRE1B/Apollo, plays a key role in telomeric loop (T loop) formation by generating 3' single- stranded overhang at the leading end telomeres: T loops have been proposed to protect chromosome ends from degradation and repair. Required both to recruit DCLRE1B/Apollo to telomeres and activate the exonuclease activity of DCLRE1B/Apollo. Preferentially binds to positive supercoiled DNA. Together with DCLRE1B/Apollo, required to control the amount of DNA topoisomerase (TOP1, TOP2A and TOP2B) needed for telomere replication during fork passage and prevent aberrant telomere topology. Recruits TERF2IP/RAP1 to telomeres, thereby participating in to repressing homology- directed repair (HDR), which can affect telomere length. 

Sequence Annotation

 DOMAIN 483 540 HTH myb-type.
 DNA_BIND 511 536 H-T-H motif (By similarity).
 REGION 87 290 TRFH dimerization.
 MOTIF 373 377 Nuclear localization signal (Potential).
 MOD_RES 30 30 Phosphoserine.
 MOD_RES 62 62 Asymmetric dimethylarginine; by PRMT1 (By
 MOD_RES 63 63 Omega-N-methylarginine (By similarity).
 MOD_RES 233 233 Phosphothreonine; by ATM (By similarity).
 MOD_RES 364 364 Phosphoserine.
 MOD_RES 367 367 Phosphoserine (By similarity).  

Keyword

 Alternative splicing; Cell cycle; Chromosome; Complete proteome; DNA-binding; Methylation; Nucleus; Phosphoprotein; Reference proteome; Telomere. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 541 AA 

Protein Sequence

Gene Ontology

 GO:0001673; C:male germ cell nucleus; IDA:MGI.
 GO:0000784; C:nuclear chromosome, telomeric region; IDA:MGI.
 GO:0005654; C:nucleoplasm; TAS:Reactome.
 GO:0003682; F:chromatin binding; IEA:InterPro.
 GO:0003691; F:double-stranded telomeric DNA binding; IMP:BHF-UCL.
 GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
 GO:0001701; P:in utero embryonic development; IMP:MGI.
 GO:0032206; P:positive regulation of telomere maintenance; IDA:MGI.
 GO:0031848; P:protection from non-homologous end joining at telomere; IMP:UniProtKB. 

Interpro

 IPR009057; Homeodomain-like.
 IPR017930; Myb_dom.
 IPR001005; SANT/Myb.
 IPR017357; Telomere_repeat-bd-1/2.
 IPR013867; Telomere_rpt-bd_fac_dimer_dom. 

Pfam

 PF00249; Myb_DNA-binding
 PF08558; TRF 

SMART

 SM00717; SANT 

PROSITE

 PS51294; HTH_MYB 

PRINTS