UniProt Accession

 TAUD_ECOLI; P37610; P77797; Q2MC57; Q47540 

Genbank Protein ID

 D85613; U73857; U00096; AP009048; M24488 

Genbank Nucleotide ID

 BAA12841.1; AAB18091.1; AAC73471.1; BAE76149.1 

Protein Name

 Alpha-ketoglutarate-dependent taurine dioxygenase 

Protein Synonyms/Alias

 2-aminoethanesulfonate dioxygenase; Sulfate starvation-induced protein 3; SSI3 

Gene Name

 tauD 

Gene Synonyms/Alias

 ssiD; yaiG; b0368; JW0360 

Created Date

 July 27, 2013 

Organism

 Escherichia coli (strain K12) 

NCBI Taxa ID

 83333 

Lysine Modification

Position	Peptide	Type	References
197	RTHPVSGKQALFVNE	acetylation	[1]
277	RATILGDKPFYRAG*	acetylation	[1]

Reference

 [1] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli.
 Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C.
 Mol Cell. 2013 Jul 25;51(2):265-72. [PMID: 23830618] 

Functional Description

 Catalyzes the conversion of taurine and alpha ketoglutarate to sulfite, aminoacetaldehyde and succinate. Required for the utilization of taurine (2-aminoethanesulfonic acid) as an alternative sulfur source. Pentane-sulfonic acid, 3- (N-morpholino)propanesulfonic acid and 1,3-dioxo-2- isoindolineethanesulfonic acid are also substrates for this enzyme. 

Sequence Annotation

 METAL 99 99 Iron; catalytic.
 METAL 101 101 Iron; catalytic.
 METAL 255 255 Iron; catalytic.
 BINDING 70 70 Substrate.
 BINDING 73 73 Substrate.
 BINDING 95 95 Substrate.
 BINDING 102 102 Substrate; via amide nitrogen.
 BINDING 126 126 2-oxoglutarate.
 BINDING 240 240 2-oxoglutarate.
 BINDING 266 266 2-oxoglutarate.
 BINDING 270 270 2-oxoglutarate.
 BINDING 270 270 Substrate.
 MOD_RES 128 128 3-hydroxytryptophan; by autocatalysis.
 MOD_RES 240 240 3-hydroxytryptophan; by autocatalysis.
 MOD_RES 248 248 3-hydroxytryptophan; by autocatalysis.  

Keyword

 3D-structure; Complete proteome; Dioxygenase; Direct protein sequencing; Hydroxylation; Iron; Metal-binding; Oxidoreductase; Reference proteome; Vitamin C. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 283 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IDA:EcoliWiki.
 GO:0031418; F:L-ascorbic acid binding; IEA:UniProtKB-KW.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0016702; F:oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen; IEA:UniProtKB-KW.
 GO:0000908; F:taurine dioxygenase activity; IDA:EcoliWiki.
 GO:0006790; P:sulfur compound metabolic process; IMP:EcoliWiki. 

Interpro

 IPR003819; Taurine_dOase. 

Pfam

 PF02668; TauD 

SMART

  

PROSITE

  

PRINTS