UniProt Accession

 RNH2C_MOUSE; Q9CQ18; Q8R1N2 

Genbank Protein ID

 AF346604; AK018776; AK011556; BC024333 

Genbank Nucleotide ID

 AAO49175.1; BAB31401.1; BAB27694.1; AAH24333.1 

Protein Name

 Ribonuclease H2 subunit C 

Protein Synonyms/Alias

 RNase H2 subunit C; Ribonuclease HI subunit C 

Gene Name

 Rnaseh2c 

Gene Synonyms/Alias

 Ayp1 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
2	******MKNPEEAAD	acetylation	[1]

Reference

 [1] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337] 

Functional Description

 Non catalytic subunit of RNase H2, an endonuclease that specifically degrades the RNA of RNA:DNA hybrids. Participates in DNA replication, possibly by mediating the removal of lagging- strand Okazaki fragment RNA primers during DNA replication. Mediates the excision of single ribonucleotides from DNA:RNA duplexes. 

Sequence Annotation

 MOD_RES 1 1 N-acetylmethionine (By similarity).  

Keyword

 3D-structure; Acetylation; Complete proteome; Nucleus; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 166 AA 

Protein Sequence

Gene Ontology

 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0032299; C:ribonuclease H2 complex; ISS:UniProtKB.
 GO:0006401; P:RNA catabolic process; ISS:UniProtKB. 

Interpro

 IPR013924; RNase_H2_suC. 

Pfam

 PF08615; RNase_H2_suC 

SMART

  

PROSITE

  

PRINTS