CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-029881
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Uncharacterized protein CXorf57 
Protein Synonyms/Alias
  
Gene Name
 CXorf57 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
113LQDYSVKKSYPFRIQubiquitination[1]
156IIPEKQVKPEWRLPKubiquitination[1, 2, 3]
163KPEWRLPKLNHRFTTubiquitination[1]
262RNDNQVPKLLYLTTTubiquitination[2]
289QPYTYDAKNANRPSTubiquitination[1, 3]
335TNLSLSNKIRILQGPubiquitination[1, 2]
359PGASVQTKGIKPGMPubiquitination[2]
362SVQTKGIKPGMPSIFubiquitination[2]
382INANLQGKARKTISDacetylation[4]
400SQLWREKKFGLIDHLubiquitination[1, 2, 3]
420YPESIPRKFMFEHRKubiquitination[1]
427KFMFEHRKFLSDQYNubiquitination[1, 3]
454PPKLDDFKSARSLGHubiquitination[5]
528AVAGDIIKAATELDRubiquitination[1, 3, 5, 6]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [3] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [4] Monoclonal antibody cocktail as an enrichment tool for acetylome analysis.
 Shaw PG, Chaerkady R, Zhang Z, Davidson NE, Pandey A.
 Anal Chem. 2011 May 15;83(10):3623-6. [PMID: 21466224]
 [5] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [6] Proteome-wide identification of ubiquitylation sites by conjugation of engineered lysine-less ubiquitin.
 Oshikawa K, Matsumoto M, Oyamada K, Nakayama KI.
 J Proteome Res. 2012 Feb 3;11(2):796-807. [PMID: 22053931
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 566 AA 
Protein Sequence
NNEDPYGDIW LTDKQPEEHN FSDTKIISLS HLEMTWTNRR NFPALLVRIL HKSKLRYYGK 60
PDKKMIEPYQ TFLEVADSSG TVSVIMWNAL CPEWYKSLRV GLVLLLQDYS VKKSYPFRIQ 120
PVPVDPQIKL ISTMEICLNL RDPPTNIIII PEKQVKPEWR LPKLNHRFTT RSELDDMPEN 180
CICDVIGLLV FVGRVQRSKK KENREDFWSY RWIHIADGTS EQPFIVELFS TSQPEIFENI 240
YPMAYFVCTQ LKVVRNDNQV PKLLYLTTTN ESGVFITGHR GQPYTYDAKN ANRPSTSQAA 300
RVEIQERNGK RHQDDEPVNS QYFQTTSTNL SLSNKIRILQ GPHANPVAVP QPGASVQTKG 360
IKPGMPSIFN RRANINANLQ GKARKTISDR WESQLWREKK FGLIDHLHYS RVYPESIPRK 420
FMFEHRKFLS DQYNSQPAKY VPPEGRPPKL DDFKSARSLG HFEVTILGLN HEIAIDVAFL 480
PMYCPEDIRT SQIDTLLTSM NYSCAYPQDT TGNDRLPGPR AVAGDIIKAA TELDRVHIVG 540
ILDICNLGNN KVEVYLHKIY SPENTS 566 
Gene Ontology
  
Interpro
 IPR012340; NA-bd_OB-fold. 
Pfam
  
SMART
  
PROSITE
  
PRINTS