UniProt Accession

 A8K401_HUMAN; A8K401 

Genbank Protein ID

 AK290766; AK312649; CH471109; CH471109 

Genbank Nucleotide ID

 BAF83455.1; BAG35532.1; EAW94680.1; EAW94681.1 

Protein Name

 Prohibitin, isoform CRA_a 

Protein Synonyms/Alias

 cDNA FLJ78511, highly similar to Homo sapiens prohibitin (PHB), mRNA; cDNA, FLJ93035, Homo sapiens prohibitin (PHB), mRNA 

Gene Name

 PHB 

Gene Synonyms/Alias

 hCG_29613 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
4	****MAAKVFESIGK	ubiquitination	[1]
128	SITTEILKSVVARFD	ubiquitination	[2]

Reference

 [1] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965]
 [2] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 

Functional Description

  

Sequence Annotation

  

Keyword

  

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 272 AA 

Protein Sequence

Gene Ontology

 GO:0005743; C:mitochondrial inner membrane; IEA:Compara.
 GO:0005634; C:nucleus; IEA:Compara.
 GO:0000981; F:sequence-specific DNA binding RNA polymerase II transcription factor activity; IEA:Compara.
 GO:0071897; P:DNA biosynthetic process; IEA:Compara.
 GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IEA:Compara. 

Interpro

 IPR001107; Band_7.
 IPR000163; Prohibitin. 

Pfam

 PF01145; Band_7 

SMART

 SM00244; PHB 

PROSITE

  

PRINTS

 PR00679; PROHIBITIN.