CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-013031
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 26S proteasome non-ATPase regulatory subunit 1 
Protein Synonyms/Alias
 26S proteasome regulatory subunit RPN2; 26S proteasome regulatory subunit S1 
Gene Name
 Psmd1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
136RLEGIVNKMFQRCLDubiquitination[1]
302DPMETEEKTASAVAGubiquitination[1]
310TASAVAGKTPDASPEacetylation[2]
310TASAVAGKTPDASPEubiquitination[1]
354NTDLMILKNTKDAVRacetylation[3]
354NTDLMILKNTKDAVRubiquitination[1]
574IESLCRDKDPILRRSubiquitination[1]
720YSKVINDKHDDVMAKacetylation[2, 4]
720YSKVINDKHDDVMAKubiquitination[1]
803KMPKVQYKSNCKPSTubiquitination[1]
807VQYKSNCKPSTFAYPubiquitination[1]
821PAPLEVPKEKEKEKVubiquitination[1]
838AVLSITAKAKKKEKEubiquitination[1]
890RVMPAQLKVLSMTETubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337]
 [3] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [4] Calorie restriction and SIRT3 trigger global reprogramming of the mitochondrial protein acetylome.
 Hebert AS, Dittenhafer-Reed KE, Yu W, Bailey DJ, Selen ES, Boersma MD, Carson JJ, Tonelli M, Balloon AJ, Higbee AJ, Westphall MS, Pagliarini DJ, Prolla TA, Assadi-Porter F, Roy S, Denu JM, Coon JJ.
 Mol Cell. 2013 Jan 10;49(1):186-99. [PMID: 23201123] 
Functional Description
 Acts as a regulatory subunit of the 26 proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins (By similarity). 
Sequence Annotation
 REPEAT 403 436 PC 1.
 REPEAT 441 474 PC 2.
 REPEAT 476 510 PC 3.
 REPEAT 511 545 PC 4.
 REPEAT 547 580 PC 5.
 REPEAT 581 616 PC 6.
 REPEAT 617 649 PC 7.
 REPEAT 651 685 PC 8.
 REPEAT 686 726 PC 9.
 REPEAT 729 761 PC 10.
 MOD_RES 1 1 N-acetylmethionine (By similarity).
 MOD_RES 273 273 Phosphothreonine.
 MOD_RES 290 290 Phosphoserine (By similarity).
 MOD_RES 310 310 N6-acetyllysine (By similarity).
 MOD_RES 311 311 Phosphothreonine.
 MOD_RES 315 315 Phosphoserine.  
Keyword
 Acetylation; Complete proteome; Phosphoprotein; Proteasome; Reference proteome; Repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 953 AA 
Protein Sequence
MITSAAGIIS LLDEEEPQLK EFALHKLNAV VNDFWAEISE SVDKIEVLYE DEGFRSRQFA 60
ALVASKVFYH LGAFEESLNY ALGAGDLFNV NDNSEYVETI IAKCIDHYTK QCVENADLPE 120
GEKKPIDQRL EGIVNKMFQR CLDDHKYKQA IGIALETRRL DVFEKTILES NDVPGMLAYS 180
LKLCMSLMQN KQFRNKVLRV LVKIYMNLEK PDFINVCQCL IFLDDPQAVS DILEKLVKED 240
NLLMAYQICF DLYESASQQF LSSVIQNLRT VGTPIASVPG STNTGTVPGS EKDSDPMETE 300
EKTASAVAGK TPDASPEPKD QTLKMIKILS GEMAIELHLQ FLIRNNNTDL MILKNTKDAV 360
RNSVCHTATV IANSFMHCGT TSDQFLRDNL EWLARATNWA KFTATASLGV IHKGHEKEAL 420
QLMATYLPKD TSPGSAYQEG GGLYALGLIH ANHGGDIIDY LLNQLKNASN DIVRHGGSLG 480
LGLAAMGTAR QDVYDLLKTN LYQDDAVTGE AAGLALGLVM LGSKNAQAIE DMVGYAQETQ 540
HEKILRGLAV GIALVMYGRM EEADALIESL CRDKDPILRR SGMYTVAMAY CGSGNNKAIR 600
RLLHVAVSDV NDDVRRAAVE SLGFILFRTP EQCPSVVSLL SESYNPHVRY GAAMALGICC 660
AGTGNKEAIN LLEPMTNDPV NYVRQGALIA SALIMIQQTE ITCPKVNQFR QLYSKVINDK 720
HDDVMAKFGA ILAQGILDAG GHNVTISLQS RTGHTHMPSV VGVLVFTQFW FWFPLSHFLS 780
LAYTPTCVIG LNKDLKMPKV QYKSNCKPST FAYPAPLEVP KEKEKEKVST AVLSITAKAK 840
KKEKEKEKKE EEKMEVDEAE KKEEKEKKKE PEPNFQLLDN PARVMPAQLK VLSMTETCRY 900
QPFKPLSIGG IIILKDTSED VEELVEPVAA HGPKIEEEEQ EPEPPEPFEY IDD 953 
Gene Ontology
 GO:0022624; C:proteasome accessory complex; IDA:UniProtKB.
 GO:0030234; F:enzyme regulator activity; IEA:InterPro.
 GO:0050790; P:regulation of catalytic activity; IEA:GOC.
 GO:0042176; P:regulation of protein catabolic process; IEA:InterPro. 
Interpro
 IPR016642; 26S_Psome_Rpn2.
 IPR002015; APC_proteasome.
 IPR011989; ARM-like.
 IPR016024; ARM-type_fold. 
Pfam
 PF01851; PC_rep 
SMART
  
PROSITE
  
PRINTS