CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-006285
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 L-lactate dehydrogenase [cytochrome] 
Protein Synonyms/Alias
  
Gene Name
 lldD 
Gene Synonyms/Alias
 lctD; b3605; JW3580 
Created Date
 July 27, 2013 
Organism
 Escherichia coli (strain K12) 
NCBI Taxa ID
 83333 
Lysine Modification
Position
Peptide
Type
References
53ALRQRILKNMSDLSLacetylation[1]
356NLIEKEMKVAMTLTGacetylation[1]
381SLVQGLGKELPAALAacetylation[1]
Reference
 [1] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli.
 Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C.
 Mol Cell. 2013 Jul 25;51(2):265-72. [PMID: 23830618] 
Functional Description
  
Sequence Annotation
 DOMAIN 1 380 FMN hydroxy acid dehydrogenase.
 NP_BIND 306 330 FMN (By similarity).
 ACT_SITE 275 275 Proton acceptor (By similarity).
 BINDING 24 24 Substrate (Potential).
 BINDING 106 106 FMN (By similarity).
 BINDING 127 127 FMN (By similarity).
 BINDING 129 129 Substrate (By similarity).
 BINDING 155 155 FMN (By similarity).
 BINDING 164 164 Substrate (By similarity).
 BINDING 251 251 FMN (By similarity).
 BINDING 278 278 Substrate (Potential).  
Keyword
 Complete proteome; Flavoprotein; FMN; Oxidoreductase; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 396 AA 
Protein Sequence
MIISAASDYR AAAQRILPPF LFHYMDGGAY SEYTLRRNVE DLSEVALRQR ILKNMSDLSL 60
ETTLFNEKLS MPVALAPVGL CGMYARRGEV QAAKAADAHG IPFTLSTVSV CPIEEVAPAI 120
KRPMWFQLYV LRDRGFMRNA LERAKAAGCS TLVFTVDMPT PGARYRDAHS GMSGPNAAMR 180
RYLQAVTHPQ WAWDVGLNGR PHDLGNISAY LGKPTGLEDY IGWLGNNFDP SISWKDLEWI 240
RDFWDGPMVI KGILDPEDAR DAVRFGADGI VVSNHGGRQL DGVLSSARAL PAIADAVKGD 300
IAILADSGIR NGLDVVRMIA LGADTVLLGR AFLYALATAG QAGVANLLNL IEKEMKVAMT 360
LTGAKSISEI TQDSLVQGLG KELPAALAPM AKGNAA 396 
Gene Ontology
 GO:0005886; C:plasma membrane; IDA:EcoCyc.
 GO:0010181; F:FMN binding; IDA:EcoCyc.
 GO:0004460; F:L-lactate dehydrogenase (cytochrome) activity; IEA:HAMAP.
 GO:0004459; F:L-lactate dehydrogenase activity; IDA:EcoCyc.
 GO:0009060; P:aerobic respiration; IEP:EcoCyc.
 GO:0042355; P:L-fucose catabolic process; IEP:EcoCyc.
 GO:0019516; P:lactate oxidation; IMP:EcoCyc. 
Interpro
 IPR013785; Aldolase_TIM.
 IPR012133; Alpha-hydoxy_acid_DH_FMN.
 IPR000262; FMN-dep_DH.
 IPR008259; FMN_hydac_DH_AS.
 IPR020920; L-lactate_DHase_cyt. 
Pfam
 PF01070; FMN_dh 
SMART
  
PROSITE
 PS00557; FMN_HYDROXY_ACID_DH_1
 PS51349; FMN_HYDROXY_ACID_DH_2 
PRINTS