UniProt Accession

 LASP1_MOUSE; Q61792; Q62416 

Genbank Protein ID

 X96973; AK078445; BC010840; U58882 

Genbank Nucleotide ID

 CAA65659.1; BAC37278.1; AAH10840.1; AAC52639.1 

Protein Name

 LIM and SH3 domain protein 1 

Protein Synonyms/Alias

 LASP-1; Metastatic lymph node gene 50 protein; MLN 50 

Gene Name

 Lasp1 

Gene Synonyms/Alias

 Mln50 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
27	CLDKYWHKACFHCET	acetylation	[1]

Reference

 [1] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441] 

Functional Description

 Plays an important role in the regulation of dynamic actin-based, cytoskeletal activities. Agonist-dependent changes in LASP1 phosphorylation may also serve to regulate actin-associated ion transport activities, not only in the parietal cell but also in certain other F-actin-rich secretory epithelial cell types (By similarity). 

Sequence Annotation

 DOMAIN 5 56 LIM zinc-binding.
 REPEAT 61 95 Nebulin 1.
 REPEAT 97 131 Nebulin 2.
 DOMAIN 204 263 SH3.
 MOD_RES 1 1 N-acetylmethionine (By similarity).
 MOD_RES 42 42 N6-acetyllysine (By similarity).
 MOD_RES 68 68 Phosphothreonine (By similarity).
 MOD_RES 104 104 Phosphothreonine (By similarity).
 MOD_RES 118 118 Phosphoserine (By similarity).
 MOD_RES 156 156 Phosphothreonine; by PKA.  

Keyword

 Acetylation; Actin-binding; Complete proteome; Cytoplasm; Cytoskeleton; Ion transport; LIM domain; Metal-binding; Phosphoprotein; Reference proteome; Repeat; SH3 domain; Transport; Zinc. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 263 AA 

Protein Sequence

Gene Ontology

 GO:0030864; C:cortical actin cytoskeleton; ISS:UniProtKB.
 GO:0005925; C:focal adhesion; IDA:MGI.
 GO:0051015; F:actin filament binding; IDA:MGI.
 GO:0015075; F:ion transmembrane transporter activity; ISS:UniProtKB.
 GO:0008270; F:zinc ion binding; IEA:InterPro. 

Interpro

 IPR000900; Nebulin_35r-motif.
 IPR001452; SH3_domain.
 IPR001781; Znf_LIM. 

Pfam

 PF00412; LIM
 PF00880; Nebulin
 PF00018; SH3_1 

SMART

 SM00132; LIM
 SM00227; NEBU
 SM00326; SH3 

PROSITE

 PS00478; LIM_DOMAIN_1
 PS50023; LIM_DOMAIN_2
 PS51216; NEBULIN
 PS50002; SH3 

PRINTS

 PR00452; SH3DOMAIN.