CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-007165
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Nicotinate phosphoribosyltransferase 
Protein Synonyms/Alias
 NAPRTase 
Gene Name
 NPT1 
Gene Synonyms/Alias
 YOR209C 
Created Date
 July 27, 2013 
Organism
 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 
NCBI Taxa ID
 559292 
Lysine Modification
Position
Peptide
Type
References
94YISSSNYKLHPEEQIacetylation[1]
163QLEQAEKKAETLFDNubiquitination[2]
316HHYHDVLKLPKFSKIacetylation[1]
322LKLPKFSKIICYSDSubiquitination[2]
406MGDPATVKRVKEELGubiquitination[2]
409PATVKRVKEELGYTEubiquitination[2]
Reference
 [1] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae.
 Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C.
 Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [PMID: 22865919]
 [2] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301] 
Functional Description
 Essential for growth under anaerobic conditions. 
Sequence Annotation
  
Keyword
 3D-structure; Complete proteome; Cytoplasm; Ligase; Nucleus; Pyridine nucleotide biosynthesis; Reference proteome; Transferase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 429 AA 
Protein Sequence
MSEPVIKSLL DTDMYKITMH AAVFTNFPDV TVTYKYTNRS SQLTFNKEAI NWLKEQFSYL 60
GNLRFTEEEI EYLKQEIPYL PSAYIKYISS SNYKLHPEEQ ISFTSEEIEG KPTHYKLKIL 120
VSGSWKDTIL YEIPLLSLIS EAYFKFVDID WDYENQLEQA EKKAETLFDN GIRFSEFGTR 180
RRRSLKAQDL IMQGIMKAVN GNPDRNKSLL LGTSNILFAK KYGVKPIGTV AHEWVMGVAS 240
ISEDYLHANK NAMDCWINTF GAKNAGLALT DTFGTDDFLK SFRPPYSDAY VGVRQDSGDP 300
VEYTKKISHH YHDVLKLPKF SKIICYSDSL NVEKAITYSH AAKENGMLAT FGIGTNFTND 360
FRKKSEPQVK SEPLNIVIKL LEVNGNHAIK ISDNLGKNMG DPATVKRVKE ELGYTERSWS 420
GDNEAHRWT 429 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0005634; C:nucleus; IDA:SGD.
 GO:0004516; F:nicotinate phosphoribosyltransferase activity; IDA:SGD.
 GO:0004514; F:nicotinate-nucleotide diphosphorylase (carboxylating) activity; IEA:InterPro.
 GO:0000183; P:chromatin silencing at rDNA; IMP:SGD.
 GO:0006348; P:chromatin silencing at telomere; IMP:SGD.
 GO:0009435; P:NAD biosynthetic process; IEA:UniProtKB-UniPathway.
 GO:0019358; P:nicotinate nucleotide salvage; IDA:SGD.
 GO:0001302; P:replicative cell aging; IMP:SGD. 
Interpro
 IPR006406; Nic_PRibTrfase.
 IPR015977; Nic_PRibTrfase-like.
 IPR007229; Nic_PRibTrfase-rel.
 IPR002638; Quinolinate_PRibosylTrfase_C. 
Pfam
 PF04095; NAPRTase 
SMART
  
PROSITE
  
PRINTS