UniProt Accession

 DPOD3_HUMAN; Q15054; B7ZAI6 

Genbank Protein ID

 D26018; AK316301; CH471076 

Genbank Nucleotide ID

 BAA05039.1; BAH14672.1; EAW74942.1 

Protein Name

 DNA polymerase delta subunit 3 

Protein Synonyms/Alias

 DNA polymerase delta subunit p66 

Gene Name

 POLD3 

Gene Synonyms/Alias

 KIAA0039 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
131	SNLQNCSKFSAIQCA	ubiquitination	[1]
216	KETKTEAKEVTNASA	acetylation	[2]
227	NASAAGNKAPGKGNM	acetylation	[2]
241	MMSNFFGKAAMNKFK	acetylation	[2]
258	LDSEQAVKEEKIVEQ	sumoylation	[3]
444	REERKGPKKGTAALG	sumoylation	[3]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Spermidine and resveratrol induce autophagy by distinct pathways converging on the acetylproteome.
 Morselli E, Mariño G, Bennetzen MV, Eisenberg T, Megalou E, Schroeder S, Cabrera S, Bénit P, Rustin P, Criollo A, Kepp O, Galluzzi L, Shen S, Malik SA, Maiuri MC, Horio Y, López-Otín C, Andersen JS, Tavernarakis N, Madeo F, Kroemer G.
 J Cell Biol. 2011 Feb 21;192(4):615-29. [PMID: 21339330]
 [3] The p66 and p12 subunits of DNA polymerase delta are modified by ubiquitin and ubiquitin-like proteins.
 Liu G, Warbrick E.
 Biochem Biophys Res Commun. 2006 Oct 13;349(1):360-6. [PMID: 16934752] 

Functional Description

 Required for optimal DNA polymerase delta activity. 

Sequence Annotation

 MOD_RES 2 2 N-acetylalanine.
 MOD_RES 307 307 Phosphoserine.
 MOD_RES 407 407 Phosphoserine.
 MOD_RES 409 409 Phosphoserine.
 MOD_RES 411 411 Phosphothreonine.
 MOD_RES 413 413 Phosphoserine.
 MOD_RES 458 458 Phosphoserine.  

Keyword

 3D-structure; Acetylation; Complete proteome; Direct protein sequencing; DNA replication; DNA-directed DNA polymerase; Nucleotidyltransferase; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; Transferase. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 466 AA 

Protein Sequence

Gene Ontology

 GO:0043625; C:delta DNA polymerase complex; NAS:UniProtKB.
 GO:0005739; C:mitochondrion; IDA:HPA.
 GO:0005654; C:nucleoplasm; TAS:Reactome.
 GO:0003887; F:DNA-directed DNA polymerase activity; NAS:UniProtKB.
 GO:0006284; P:base-excision repair; TAS:Reactome.
 GO:0006271; P:DNA strand elongation involved in DNA replication; TAS:Reactome.
 GO:0000731; P:DNA synthesis involved in DNA repair; NAS:UniProtKB.
 GO:0006298; P:mismatch repair; NAS:UniProtKB.
 GO:0000278; P:mitotic cell cycle; TAS:Reactome.
 GO:0006297; P:nucleotide-excision repair, DNA gap filling; IMP:UniProtKB.
 GO:0000722; P:telomere maintenance via recombination; TAS:Reactome.
 GO:0032201; P:telomere maintenance via semi-conservative replication; TAS:Reactome.
 GO:0006283; P:transcription-coupled nucleotide-excision repair; TAS:Reactome. 

Interpro

 IPR019038; DNA_polymerase_subunit_Cdc27. 

Pfam

 PF09507; CDC27 

SMART

  

PROSITE

  

PRINTS