CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-011983
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Triadin 
Protein Synonyms/Alias
  
Gene Name
 TRDN 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
226KKEVKGGKQEKVKQTacetylation[1]
229VKGGKQEKVKQTAAKacetylation[1]
625SEKESKEKADMKHLRmethylation[2]
Reference
 [1] Regulation of cellular metabolism by protein lysine acetylation.
 Zhao S, Xu W, Jiang W, Yu W, Lin Y, Zhang T, Yao J, Zhou L, Zeng Y, Li H, Li Y, Shi J, An W, Hancock SM, He F, Qin L, Chin J, Yang P, Chen X, Lei Q, Xiong Y, Guan KL.
 Science. 2010 Feb 19;327(5968):1000-4. [PMID: 20167786]
 [2] Large-scale global identification of protein lysine methylation in vivo.
 Cao XJ, Arnaudo AM, Garcia BA.
 Epigenetics. 2013 May 1;8(5):477-85. [PMID: 23644510] 
Functional Description
 May be involved in anchoring calsequestrin to the junctional sarcoplasmic reticulum and allowing its functional coupling with the ryanodine receptor (By similarity). 
Sequence Annotation
 CARBOHYD 75 75 N-linked (GlcNAc...) (Potential).
 CARBOHYD 647 647 N-linked (GlcNAc...) (Potential).
 DISULFID 270 270 Interchain (By similarity).
 DISULFID 691 691 Interchain (By similarity).  
Keyword
 Alternative splicing; Cell membrane; Complete proteome; Disease mutation; Disulfide bond; Glycoprotein; Membrane; Phosphoprotein; Polymorphism; Reference proteome; Sarcoplasmic reticulum; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 729 AA 
Protein Sequence
MTEITAEGNA STTTTVIDSK NGSVPKSPGK VLKRTVTEDI VTTFSSPAAW LLVIALIITW 60
SAVAIVMFDL VDYKNFSASS IAKIGSDPLK LVRDAMEETT DWIYGFFSLL SDIISSEDEE 120
DDDGDEDTDK GEIDEPPLRK KEIHKDKTEK QEKPERKIQT KVTHKEKEKG KEKVREKEKP 180
EKKATHKEKI EKKEKPETKT LAKEQKKAKT AEKSEEKTKK EVKGGKQEKV KQTAAKVKEV 240
QKTPSKPKEK EDKEKAAVSK HEQKDQYAFC RYMIDIFVHG DLKPGQSPAI PPPLPTEQAS 300
RPTPASPALE EKEGEKKKAE KKVTSETKKK EKEDIKKKSE KETAIDVEKK EPGKASETKQ 360
GTVKIAAQAA AKKDEKKEDS KKTKKPAEVE QPKGKKQEKK EKHVEPAKSP KKEHSVPSDK 420
QVKAKTERAK EEIGAVSIKK AVPGKKEEKT TKTVEQEIRK EKSGKTSSIL KDKEPIKGKE 480
EKVPASLKEK EPETKKDEKM SKAGKEVKPK PPQLQGKKEE KPEPQIKKEA KPAISEKVQI 540
HKQDIVKPEK TVSHGKPEEK VLKQVKAVTI EKTAKPKPTK KAEHREREPP SIKTDKPKPT 600
PKGTSEVTES GKKKTEISEK ESKEKADMKH LREEKVSTRK ESLQLHNVTK AEKPARVSKD 660
VEDVPASKKA KEGTEDVSPT KQKSPISFFQ CVYLDGYNGY GFQFPFTPAD RPGESSGQAN 720
SPGQKQQGQ 729 
Gene Ontology
 GO:0034704; C:calcium channel complex; TAS:BHF-UCL.
 GO:0014701; C:junctional sarcoplasmic reticulum membrane; TAS:BHF-UCL.
 GO:0005886; C:plasma membrane; IDA:UniProtKB.
 GO:0033018; C:sarcoplasmic reticulum lumen; TAS:BHF-UCL.
 GO:0044325; F:ion channel binding; ISS:BHF-UCL.
 GO:0030674; F:protein binding, bridging; ISS:BHF-UCL.
 GO:0060047; P:heart contraction; IEA:Compara.
 GO:0034220; P:ion transmembrane transport; TAS:Reactome.
 GO:0006936; P:muscle contraction; TAS:ProtInc.
 GO:0060315; P:negative regulation of ryanodine-sensitive calcium-release channel activity; TAS:BHF-UCL.
 GO:0060316; P:positive regulation of ryanodine-sensitive calcium-release channel activity; TAS:BHF-UCL.
 GO:0010649; P:regulation of cell communication by electrical coupling; TAS:BHF-UCL.
 GO:0051279; P:regulation of release of sequestered calcium ion into cytosol; TAS:BHF-UCL.
 GO:0014808; P:release of sequestered calcium ion into cytosol by sarcoplasmic reticulum; IEA:Compara. 
Interpro
 IPR007943; Asp-B-hydro/Triadin_dom.
 IPR010798; Triadin. 
Pfam
 PF05279; Asp-B-Hydro_N 
SMART
  
PROSITE
  
PRINTS