| Tag | Content |
|---|
| CPLM ID | CPLM-012320 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Nuclear factor erythroid 2-related factor 1 |
Protein Synonyms/Alias | NF-E2-related factor 1; NFE2-related factor 1; Locus control region-factor 1; Nuclear factor, erythroid derived 2, like 1; Transcription factor 11; TCF-11; Transcription factor HBZ17; Transcription factor LCR-F1 |
Gene Name | NFE2L1 |
Gene Synonyms/Alias | HBZ17; NRF1; TCF11 |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 70 | DGYGIHPKSIDLDNY | ubiquitination | [1] | | 599 | KIPFTNDKIINLPVE | ubiquitination | [1] |
|
Reference | [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization. Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW. Nature. 2013 Apr 18;496(7445):372-6. [ PMID: 23503661] |
Functional Description | Activates erythroid-specific, globin gene expression. |
Sequence Annotation | DOMAIN 654 717 bZIP.
REGION 656 675 Basic motif (By similarity).
REGION 682 696 Leucine-zipper (By similarity). |
Keyword | Activator; Alternative splicing; Complete proteome; DNA-binding; Endoplasmic reticulum; Membrane; Nucleus; Polymorphism; Reference proteome; Signal-anchor; Transcription; Transcription regulation; Transmembrane; Transmembrane helix. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 772 AA |
Protein Sequence | MLSLKKYLTE GLLQFTILLS LIGVRVDVDT YLTSQLPPLR EIILGPSSAY TQTQFHNLRN 60
TLDGYGIHPK SIDLDNYFTA RRLLSQVRAL DRFQVPTTEV NAWLVHRDPE GSVSGSQPNS 120
GLALESSSGL QDVTGPDNGV RESETEQGFG EDLEDLGAVA PPVSGDLTKE DIDLIDILWR 180
QDIDLGAGRE VFDYSHRQKE QDVEKELRDG GEQDTWAGEG AEALARNLLV DGETGESFPA 240
QFPADISSIT EAVPSESEPP ALQNNLLSPL LTGTESPFDL EQQWQDLMSI MEMQAMEVNT 300
SASEILYSAP PGDPLSTNYS LAPNTPINQN VSLHQASLGG CSQDFLLFSP EVESLPVASS 360
STLLPLAPSN STSLNSTFGS TNLTGLFFPP QLNGTANDTA GPELPDPLGG LLDEAMLDEI 420
SLMDLAIEEG FNPVQASQLE EEFDSDSGLS LDSSHSPSSL SSSEGSSSSS SSSSSSSSSA 480
SSSASSSFSE EGAVGYSSDS ETLDLEEAEG AVGYQPEYSK FCRMSYQDPA QLSCLPYLEH 540
VGHNHTYNMA PSALDSADLP PPSALKKGSK EKQADFLDKQ MSRDEHRARA MKIPFTNDKI 600
INLPVEEFNE LLSKYQLSEA QLSLIRDIRR RGKNKMAAQN CRKRKLDTIL NLERDVEDLQ 660
RDKARLLREK VEFLRSLRQM KQKVQSLYQE VFGRLRDENG RPYSPSQYAL QYAGDGSVLL 720
IPRTMADQQA RRQERKPKDR RK 742 |
Gene Ontology | GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell. GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. GO:0043565; F:sequence-specific DNA binding; IEA:InterPro. GO:0003700; F:sequence-specific DNA binding transcription factor activity; TAS:ProtInc. GO:0003712; F:transcription cofactor activity; TAS:ProtInc. GO:0009653; P:anatomical structure morphogenesis; TAS:ProtInc. GO:0006783; P:heme biosynthetic process; TAS:ProtInc. GO:0006954; P:inflammatory response; TAS:ProtInc. GO:0006366; P:transcription from RNA polymerase II promoter; TAS:ProtInc. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |