CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-018119
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Beta-ureidopropionase 
Protein Synonyms/Alias
 Beta-alanine synthase; N-carbamoyl-beta-alanine amidohydrolase 
Gene Name
 Upb1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
26PDDLAQVKRILYGKQubiquitination[1]
32VKRILYGKQTRNLDLubiquitination[1]
55SERNFELKGYAFGAAubiquitination[1]
63GYAFGAAKEQQRCPQubiquitination[1]
132FAFCTREKLPWTEFAubiquitination[1]
153LTTRFCQKLAKKHNMubiquitination[1]
157FCQKLAKKHNMVVVSubiquitination[1]
305FTSGDGKKAHHDLGYubiquitination[1]
374RELAEAVKPNYSPNIubiquitination[1]
383NYSPNIVKEDLVLAPubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 Converts N-carbamyl-beta-aminoisobutyric acid and N- carbamyl-beta-alanine to, respectively, beta-aminoisobutyric acid and beta-alanine, ammonia and carbon dioxide. 
Sequence Annotation
 DOMAIN 72 366 CN hydrolase.
 METAL 97 97 Zinc (Potential).
 METAL 158 158 Zinc (Potential).
 METAL 280 280 Zinc (Potential).
 METAL 293 293 Zinc (Potential).
 METAL 307 307 Zinc (Potential).  
Keyword
 Allosteric enzyme; Complete proteome; Cytoplasm; Hydrolase; Metal-binding; Reference proteome; Zinc. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 393 AA 
Protein Sequence
MAGPEWQSLE QCLEKHLPPD DLAQVKRILY GKQTRNLDLP REALKAASER NFELKGYAFG 60
AAKEQQRCPQ IVRVGLVQNR IPLPTSAPVA EQVSALHKSI EEIAEVAAMC GVNIICFQEA 120
WNMPFAFCTR EKLPWTEFAE SAEDGLTTRF CQKLAKKHNM VVVSPILERD REHGGVLWNT 180
AVVISNSGLV MGKTRKNHIP RVGDFNESTY YMEGNLGHPV FQTQFGRIAV NICYGRHHPL 240
NWLMYSINGA EIIFNPSATI GELSESLWPI EARNAAIANH CFTCALNRVG QEHFPNEFTS 300
GDGKKAHHDL GYFYGSSYVA APDGSRTPGL SRNQDGLLVT ELNLNLCQQI NDFWTFKMTG 360
RLEMYARELA EAVKPNYSPN IVKEDLVLAP SSG 393 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0003837; F:beta-ureidopropionase activity; IEA:EC.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0019483; P:beta-alanine biosynthetic process; IEA:UniProtKB-UniPathway. 
Interpro
 IPR003010; C-N_Hydrolase. 
Pfam
 PF00795; CN_hydrolase 
SMART
  
PROSITE
 PS50263; CN_HYDROLASE 
PRINTS