| Tag | Content |
|---|
| CPLM ID | CPLM-021620 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Arsenite methyltransferase |
Protein Synonyms/Alias | Methylarsonite methyltransferase; S-adenosyl-L-methionine:arsenic(III) methyltransferase |
Gene Name | AS3MT |
Gene Synonyms/Alias | CYT19 |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 340 | GCSALELKDIITDPF | ubiquitination | [1] |
|
Reference | [1] Global identification of modular cullin-RING ligase substrates. Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ. Cell. 2011 Oct 14;147(2):459-74. [ PMID: 21963094] |
Functional Description | Catalyzes the transfer of a methyl group from AdoMet to trivalent arsenicals producing methylated and dimethylated arsenicals. It methylates arsenite to form methylarsonate, Me- AsO(3)H(2), which is reduced by methylarsonate reductase to methylarsonite, Me-As(OH)2. Methylarsonite is also a substrate and it is converted into the much less toxic compound dimethylarsinate (cacodylate), Me(2)As(O)-OH (By similarity). |
Sequence Annotation | |
Keyword | Complete proteome; Cytoplasm; Methyltransferase; Polymorphism; Reference proteome; S-adenosyl-L-methionine; Transferase. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 375 AA |
Protein Sequence | MAALRDAEIQ KDVQTYYGQV LKRSADLQTN GCVTTARPVP KHIREALQNV HEEVALRYYG 60
CGLVIPEHLE NCWILDLGSG SGRDCYVLSQ LVGEKGHVTG IDMTKGQVEV AEKYLDYHME 120
KYGFQASNVT FIHGYIEKLG EAGIKNESHD IVVSNCVINL VPDKQQVLQE AYRVLKHGGE 180
LYFSDVYTSL ELPEEIRTHK VLWGECLGGA LYWKELAVLA QKIGFCPPRL VTANLITIQN 240
KELERVIGDC RFVSATFRLF KHSKTGPTKR CQVIYNGGIT GHEKELMFDA NFTFKEGEIV 300
EVDEETAAIL KNSRFAQDFL IRPIGEKLPT SGGCSALELK DIITDPFKLA EESDSMKSRC 360
VPDAAGGCCG TKKSC 375 |
Gene Ontology | GO:0005829; C:cytosol; ISS:UniProtKB. GO:0005739; C:mitochondrion; IEA:Compara. GO:0030791; F:arsenite methyltransferase activity; ISS:UniProtKB. GO:0030792; F:methylarsonite methyltransferase activity; ISS:UniProtKB. GO:0018872; P:arsonoacetate metabolic process; ISS:UniProtKB. GO:0009404; P:toxin metabolic process; ISS:UniProtKB. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |