CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-024125
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Serine-threonine kinase receptor-associated protein 
Protein Synonyms/Alias
 UNR-interacting protein 
Gene Name
 Strap 
Gene Synonyms/Alias
 Unrip 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
73TLNKDATKAATAAADubiquitination[1]
104LAHKHIVKTVDFTQDacetylation[2]
122LLTGGQDKLLRIYDLacetylation[3]
122LLTGGQDKLLRIYDLubiquitination[1]
131LRIYDLNKPEAEPKEubiquitination[1]
156ALWCSDDKQILSADDacetylation[2]
249GEDFKLYKYDYNSGEacetylation[2]
262GEELESYKGHFGPIHacetylation[2]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [3] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377
Functional Description
 The SMN complex plays an essential role in spliceosomal snRNP assembly in the cytoplasm and is required for pre-mRNA splicing in the nucleus. STRAP may play a role in the cellular distribution of the SMN complex. Negatively regulates TGF-beta signaling but positively regulates the PDPK1 kinase activity by enhancing its autophosphorylation and by significantly reducing the association of PDPK1 with 14-3-3 protein (By similarity). 
Sequence Annotation
 REPEAT 12 56 WD 1.
 REPEAT 57 96 WD 2.
 REPEAT 98 137 WD 3.
 REPEAT 141 179 WD 4.
 REPEAT 180 212 WD 5.
 REPEAT 221 262 WD 6.
 REPEAT 263 302 WD 7.
 MOD_RES 335 335 Phosphoserine (By similarity).
 MOD_RES 338 338 Phosphoserine (By similarity).
 MOD_RES 342 342 Phosphotyrosine.  
Keyword
 Complete proteome; Cytoplasm; mRNA processing; mRNA splicing; Nucleus; Phosphoprotein; Reference proteome; Repeat; Spliceosome; WD repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 350 AA 
Protein Sequence
MAMRQTPLTC SGHTRPVVDL AFSGITPYGY FLISACKDGK PMLRQGDTGD WIGTFLGHKG 60
AVWGATLNKD ATKAATAAAD FTAKVWDAVS GDELMTLAHK HIVKTVDFTQ DSNYLLTGGQ 120
DKLLRIYDLN KPEAEPKEIS GHTSGIKKAL WCSDDKQILS ADDKTVRLWD HATMTEVKSL 180
NFNMSVSSME YIPEGEILVI TYGRSIAFHS AVSLEPIKSF EAPATINSAS LHPEKEFLVA 240
GGEDFKLYKY DYNSGEELES YKGHFGPIHC VRFSPDGELY ASGSEDGTLR LWQTVVGKTY 300
GLWKCVLPEE DSGELAKPKI GFPETAEEEL EEIASENSDS IYSSTPEVKA 350 
Gene Ontology
 GO:0030054; C:cell junction; IEA:Compara.
 GO:0005829; C:cytosol; TAS:Reactome.
 GO:0005739; C:mitochondrion; IEA:Compara.
 GO:0005886; C:plasma membrane; IEA:Compara.
 GO:0005681; C:spliceosomal complex; IEA:UniProtKB-KW.
 GO:0005102; F:receptor binding; IDA:MGI.
 GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.
 GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IDA:MGI.
 GO:0030512; P:negative regulation of transforming growth factor beta receptor signaling pathway; IDA:MGI.
 GO:0008380; P:RNA splicing; IEA:UniProtKB-KW. 
Interpro
 IPR020472; G-protein_beta_WD-40_rep.
 IPR015943; WD40/YVTN_repeat-like_dom.
 IPR001680; WD40_repeat.
 IPR019775; WD40_repeat_CS.
 IPR017986; WD40_repeat_dom. 
Pfam
 PF00400; WD40 
SMART
 SM00320; WD40 
PROSITE
 PS00678; WD_REPEATS_1
 PS50082; WD_REPEATS_2
 PS50294; WD_REPEATS_REGION 
PRINTS
 PR00320; GPROTEINBRPT.