UniProt Accession

 LGUL_SALTY; P0A1Q2; Q60003 

Genbank Protein ID

 U57364; AE006468 

Genbank Nucleotide ID

 AAC44877.1; AAL20357.1 

Protein Name

 Lactoylglutathione lyase 

Protein Synonyms/Alias

 Aldoketomutase; Glyoxalase I; Glx I; Ketone-aldehyde mutase; Methylglyoxalase; S-D-lactoylglutathione methylglyoxal lyase 

Gene Name

 gloA 

Gene Synonyms/Alias

 STM1435 

Created Date

 July 27, 2013 

Organism

 Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) 

NCBI Taxa ID

 99287 

Lysine Modification

Position	Peptide	Type	References
104	TREAGPVKGGSTIIA	acetylation	[1]

Reference

 [1] Regulation of cellular metabolism by protein lysine acetylation.
 Zhao S, Xu W, Jiang W, Yu W, Lin Y, Zhang T, Yao J, Zhou L, Zeng Y, Li H, Li Y, Shi J, An W, Hancock SM, He F, Qin L, Chin J, Yang P, Chen X, Lei Q, Xiong Y, Guan KL.
 Science. 2010 Feb 19;327(5968):1000-4. [PMID: 20167786] 

Functional Description

 Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione. 

Sequence Annotation

 METAL 5 5 Nickel (By similarity).
 METAL 56 56 Nickel (By similarity).
 METAL 74 74 Nickel (By similarity).
 METAL 122 122 Nickel (By similarity).  

Keyword

 Complete proteome; Lyase; Metal-binding; Nickel; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 135 AA 

Protein Sequence

Gene Ontology

 GO:0004462; F:lactoylglutathione lyase activity; IEA:EC.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. 

Interpro

 IPR004360; Glyas_Fos-R_dOase_dom.
 IPR004361; Glyoxalase_1.
 IPR018146; Glyoxalase_1_CS. 

Pfam

 PF00903; Glyoxalase 

SMART

  

PROSITE

 PS00934; GLYOXALASE_I_1
 PS00935; GLYOXALASE_I_2 

PRINTS