CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-036826
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Pyridoxal-dependent decarboxylase domain-containing protein 1 
Protein Synonyms/Alias
  
Gene Name
 PDXDC1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
10KNLKEAVKMLEDSQRubiquitination[1]
57EEREGLAKICRLAIHubiquitination[1]
135AFLEKLIKDDIERGRubiquitination[2]
161AAVGHTDKIGRLKELubiquitination[1]
240VAGLTSNKPTDKLRAubiquitination[2]
244TSNKPTDKLRALPLWubiquitination[1, 3]
267DGFVERIKHACQLSQubiquitination[1, 3]
315PGSDPVFKAVPVPNMubiquitination[1, 2, 3, 4, 5]
346RWLGEQLKQLVPASGubiquitination[3]
445NDDKSSLKSDPEGENubiquitination[2]
460IHAGLLKKLNELESDubiquitination[1]
471LESDLTFKIGPEYKSubiquitination[1]
477FKIGPEYKSMKSCLYubiquitination[1]
524NMTEVVRKGIQEAQVubiquitination[1]
535EAQVELQKASEERLLubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [3] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [4] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [5] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Lyase; Pyridoxal phosphate; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 697 AA 
Protein Sequence
MGKNLKEAVK MLEDSQRRTE EENGKKLISG DIPGPLQGRY ENGCAYFHEE EREGLAKICR 60
LAIHSRYEDF VVDGFNVLYN KKPVIYLSAA ARPGLGQYLC NQLGLPFPCL CRVPCNTVFG 120
SQHQMDVAFL EKLIKDDIER GRLPLLLVAN AGTAAVGHTD KIGRLKELCE QYGIWLHVEG 180
VNLATLALGY VSSSVLAAAK CDSMTMTPGP WLGLPAVPAV TLYKHDDPAL TLVAGLTSNK 240
PTDKLRALPL WLSLQYLGLD GFVERIKHAC QLSQRLQESL KKVNYIKILV EDELSSPVVV 300
FRFFQELPGS DPVFKAVPVP NMTPSGVGRE RHSCDALNRW LGEQLKQLVP ASGLTVMDLE 360
AEGTCLRFSP LMTAAVLGTR GEDVDQLVAC IESKLPVLCC TLQLREEFKQ EVEATAGLLY 420
VDDPNWSGIG VVRYEHANDD KSSLKSDPEG ENIHAGLLKK LNELESDLTF KIGPEYKSMK 480
SCLYVGMASD NVDAAELVET IAATAREIEE NSRLLENMTE VVRKGIQEAQ VELQKASEER 540
LLEEGVLRQI PVVGSVLNWF SPVQALQKGR TFNLTAGSLE STEPIYVYKA QGAGVTLPPT 600
PSGSRTKQRL PGQKPFKRSL RGSDALSETS SVSHIEDLEK VERLSSGPEQ ITLEASSTEG 660
HPGAPSPQHT DQTEAFQKGV PHPEDDHSQV EGPESLR 697 
Gene Ontology
 GO:0016831; F:carboxy-lyase activity; IEA:InterPro.
 GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
 GO:0019752; P:carboxylic acid metabolic process; IEA:InterPro. 
Interpro
 IPR002129; PyrdxlP-dep_de-COase.
 IPR015424; PyrdxlP-dep_Trfase.
 IPR015421; PyrdxlP-dep_Trfase_major_sub1.
 IPR015422; PyrdxlP-dep_Trfase_major_sub2. 
Pfam
 PF00282; Pyridoxal_deC 
SMART
  
PROSITE
  
PRINTS