UniProt Accession

 B4DSZ9_HUMAN; B4DSZ9 

Genbank Protein ID

 AP001429; AP001432; AK299991 

Genbank Nucleotide ID

 BAG61811.1 

Protein Name

 E3 ubiquitin-protein ligase TTC3 

Protein Synonyms/Alias

 cDNA FLJ59417, highly similar to Tetratricopeptide repeat protein 3 

Gene Name

 TTC3 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
27	KNDPEGIKDLIQQHV	ubiquitination	[1]
35	DLIQQHVKLQKQIED	ubiquitination	[1]
38	QQHVKLQKQIEDLQG	ubiquitination	[1, 2]
50	LQGRTANKDPIKAFY	ubiquitination	[1]
87	EKERDFRKINHEMAN	ubiquitination	[1]
155	LTLPADLKNILEKQF	ubiquitination	[1]
160	DLKNILEKQFSKSSR	ubiquitination	[1, 2, 3]
178	QDFANIMKMLRSLIQ	ubiquitination	[1]
291	EALNHFEKARTLIYR	ubiquitination	[1]
319	IEESQPQKIKMLLEK	ubiquitination	[1]
489	LRESNPPKNEEQKET	ubiquitination	[1]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [3] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473] 

Functional Description

  

Sequence Annotation

  

Keyword

 Complete proteome; Reference proteome; TPR repeat. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 612 AA 

Protein Sequence

Gene Ontology

  

Interpro

 IPR001440; TPR-1.
 IPR013026; TPR-contain_dom.
 IPR011990; TPR-like_helical. 

Pfam

 PF00515; TPR_1 

SMART

  

PROSITE

 PS50293; TPR_REGION 

PRINTS