CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-002498
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Annexin A2 
Protein Synonyms/Alias
 Annexin II; Annexin-2; Calpactin I heavy chain; Calpactin-1 heavy chain; Chromobindin-8; Lipocortin II; Placental anticoagulant protein IV; PAP-IV; Protein I; p36 
Gene Name
 Anxa2 
Gene Synonyms/Alias
 Anx2; Cal1h 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
49IETAVKTKGVDEVTIubiquitination[1]
115QYDASELKASMKGLGubiquitination[1]
148QEINRVYKEMYKTDLubiquitination[1]
302RSEVDMLKIRSEFKRubiquitination[1]
324YYIQQDTKGDYQKALubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. 
Sequence Annotation
 REPEAT 42 102 Annexin 1.
 REPEAT 114 174 Annexin 2.
 REPEAT 199 259 Annexin 3.
 REPEAT 274 334 Annexin 4.
 REGION 2 24 S100A10-binding site (Potential).
 MOD_RES 2 2 N-acetylserine (By similarity).
 MOD_RES 24 24 Phosphotyrosine; by SRC (By similarity).
 MOD_RES 26 26 Phosphoserine; by PKC (By similarity).  
Keyword
 3D-structure; Acetylation; Annexin; Basement membrane; Calcium; Calcium/phospholipid-binding; Complete proteome; Extracellular matrix; Phosphoprotein; Reference proteome; Repeat; Secreted; Ubl conjugation. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 339 AA 
Protein Sequence
MSTVHEILCK LSLEGDHSTP PSAYGSVKPY TNFDAERDAL NIETAVKTKG VDEVTIVNIL 60
TNRSNVQRQD IAFAYQRRTK KELPSALKSA LSGHLETVIL GLLKTPAQYD ASELKASMKG 120
LGTDEDSLIE IICSRTNQEL QEINRVYKEM YKTDLEKDII SDTSGDFRKL MVALAKGRRA 180
EDGSVIDYEL IDQDARELYD AGVKRKGTDV PKWISIMTER SVCHLQKVFE RYKSYSPYDM 240
LESIKKEVKG DLENAFLNLV QCIQNKPLYF ADRLYDSMKG KGTRDKVLIR IMVSRSEVDM 300
LKIRSEFKRK YGKSLYYYIQ QDTKGDYQKA LLYLCGGDD 339 
Gene Ontology
 GO:0005604; C:basement membrane; IEA:UniProtKB-SubCell.
 GO:0005769; C:early endosome; IDA:MGI.
 GO:0070062; C:extracellular vesicular exosome; IEA:Compara.
 GO:0019897; C:extrinsic to plasma membrane; IDA:MGI.
 GO:0005811; C:lipid particle; IEA:Compara.
 GO:0042470; C:melanosome; IEA:UniProtKB-SubCell.
 GO:0030496; C:midbody; IEA:Compara.
 GO:0035749; C:myelin sheath adaxonal region; IDA:BHF-UCL.
 GO:0048471; C:perinuclear region of cytoplasm; IEA:Compara.
 GO:0043234; C:protein complex; IEA:Compara.
 GO:0042383; C:sarcolemma; IDA:MGI.
 GO:0043220; C:Schmidt-Lanterman incisure; IDA:BHF-UCL.
 GO:0005509; F:calcium ion binding; IEA:InterPro.
 GO:0005544; F:calcium-dependent phospholipid binding; IEA:UniProtKB-KW.
 GO:0005546; F:phosphatidylinositol-4,5-bisphosphate binding; IEA:Compara.
 GO:0004859; F:phospholipase inhibitor activity; IEA:InterPro.
 GO:0001525; P:angiogenesis; IMP:MGI.
 GO:0007589; P:body fluid secretion; IEA:Compara.
 GO:0071229; P:cellular response to acid; IDA:MGI.
 GO:0030199; P:collagen fibril organization; IMP:MGI.
 GO:0042730; P:fibrinolysis; IMP:MGI.
 GO:0051099; P:positive regulation of binding; IMP:MGI.
 GO:0031340; P:positive regulation of vesicle fusion; IEA:Compara. 
Interpro
 IPR001464; Annexin.
 IPR018502; Annexin_repeat.
 IPR018252; Annexin_repeat_CS.
 IPR002389; AnnexinII. 
Pfam
 PF00191; Annexin 
SMART
 SM00335; ANX 
PROSITE
 PS00223; ANNEXIN 
PRINTS
 PR00196; ANNEXIN.
 PR00198; ANNEXINII.