CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-013381
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Macrophage erythroblast attacher 
Protein Synonyms/Alias
 Erythroblast macrophage protein 
Gene Name
 Maea 
Gene Synonyms/Alias
 Emp 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
31VPYETLNKRFRAAQKubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023
Functional Description
 Plays a role in erythroblast enucleation and in the development of the mature macrophages. Mediates the attachment of erythroid cell to mature macrophages, in correlation with the presence of MAEA at cell surface of mature macrophages; This MAEA- mediated contact inhibits erythroid cells apoptosis. Participates to erythroblastic island formation, which is the functional unit of definitive erythropoiesis. Associates with F-actin to regulate actin distribution in erythroblasts and macrophages. May contribute to nuclear architecture and cells division events. 
Sequence Annotation
 DOMAIN 121 153 LisH.
 DOMAIN 159 216 CTLH.
 REGION 1 124 Extracellular and involved in cell to  
Keyword
 Actin-binding; Alternative splicing; Cell cycle; Cell division; Cell membrane; Complete proteome; Cytoplasm; Cytoskeleton; Erythrocyte maturation; Membrane; Nucleus; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 396 AA 
Protein Sequence
MAVQESAAQL SMTLKVQEYP TLKVPYETLN KRFRAAQKNI DRETSHVTMV VAELEKTLSS 60
CPAVDSVVSL LDGVVEKLSV LKRKAVESIQ AEDESAKLCK RRIEHLKEHS SDQPAAASMW 120
KRKRMDRMMV EHLLRCGYYN TAVKLARQSG IEDLVNIEMF LTAKEVEESL ERRETATCLA 180
WCHDNKSRLR KMKSCLEFSL RIQEFIELVR QNKRLDAVRH ARKHFSQAEG SQLDEVRQVM 240
GMLAFPPDTH ISPYKDLLDP ARWRMLIQQF RYDNYRLHQL GNSSVFTLTL QAGLSAIKTP 300
QCYKEDGSSK SPDCPVCSRS LNKLAQPLPM AHCANSRLVC KISGDVMNEN NPPMMLPNGY 360
VYGYNSLLSI RQDDKVVCPR TKEVFHFSQA EKVYIMYAPS CYGHALGQSG GGWEPCPPAL 420
TPDPRPQPAS TFVSCDQRSV SNDKYS 446 
Gene Ontology
 GO:0015629; C:actin cytoskeleton; IDA:MGI.
 GO:0005826; C:actomyosin contractile ring; IEA:Compara.
 GO:0005887; C:integral to plasma membrane; IEA:Compara.
 GO:0016363; C:nuclear matrix; IEA:UniProtKB-SubCell.
 GO:0005819; C:spindle; IEA:Compara.
 GO:0003779; F:actin binding; IDA:MGI.
 GO:0007155; P:cell adhesion; IEA:Compara.
 GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
 GO:0051301; P:cell division; IEA:UniProtKB-KW.
 GO:0007010; P:cytoskeleton organization; IMP:MGI.
 GO:0048822; P:enucleate erythrocyte development; IMP:MGI.
 GO:0043249; P:erythrocyte maturation; IEA:UniProtKB-KW.
 GO:0033033; P:negative regulation of myeloid cell apoptotic process; IEA:Compara. 
Interpro
 IPR013144; CRA_dom.
 IPR024964; CTLH/CRA.
 IPR006595; CTLH_C.
 IPR006594; LisH_dimerisation.
 IPR027370; zf-RING_LisH. 
Pfam
 PF10607; CLTH
 PF13445; zf-RING_LisH 
SMART
 SM00757; CRA
 SM00668; CTLH
 SM00667; LisH 
PROSITE
 PS50897; CTLH
 PS50896; LISH 
PRINTS