| Tag | Content |
|---|
| CPLM ID | CPLM-020111 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Endoplasmic reticulum resident protein 44 |
Protein Synonyms/Alias | ER protein 44; ERp44; Thioredoxin domain-containing protein 4 |
Gene Name | ERP44 |
Gene Synonyms/Alias | KIAA0573; TXNDC4; UNQ532/PRO1075 |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 130 | YRGQRSVKALADYIR | ubiquitination | [1] | | 200 | SAFGDVSKPERYSGD | ubiquitination | [1] |
|
Reference | [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments. Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA. Mol Cell Proteomics. 2013 Mar;12(3):825-31. [ PMID: 23266961] |
Functional Description | Mediates thiol-dependent retention in the early secretory pathway, forming mixed disulfides with substrate proteins through its conserved CRFS motif. Inhibits the calcium channel activity of ITPR1. May have a role in the control of oxidative protein folding in the endoplasmic reticulum. Required to retain ERO1L and ERO1LB in the endoplasmic reticulum. |
Sequence Annotation | DOMAIN 30 138 Thioredoxin.
REGION 236 285 Interaction with ITPR1 (By similarity).
MOTIF 403 406 Prevents secretion from ER (Potential).
DISULFID 189 241
DISULFID 301 318 |
Keyword | 3D-structure; Chaperone; Complete proteome; Direct protein sequencing; Disulfide bond; Endoplasmic reticulum; Reference proteome; Signal; Stress response. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 406 AA |
Protein Sequence | MHPAVFLSLP DLRCSLLLLV TWVFTPVTTE ITSLDTENID EILNNADVAL VNFYADWCRF 60
SQMLHPIFEE ASDVIKEEFP NENQVVFARV DCDQHSDIAQ RYRISKYPTL KLFRNGMMMK 120
REYRGQRSVK ALADYIRQQK SDPIQEIRDL AEITTLDRSK RNIIGYFEQK DSDNYRVFER 180
VANILHDDCA FLSAFGDVSK PERYSGDNII YKPPGHSAPD MVYLGAMTNF DVTYNWIQDK 240
CVPLVREITF ENGEELTEEG LPFLILFHMK EDTESLEIFQ NEVARQLISE KGTINFLHAD 300
CDKFRHPLLH IQKTPADCPV IAIDSFRHMY VFGDFKDVLI PGKLKQFVFD LHSGKLHREF 360
HHGPDPTDTA PGEQAQDVAS SPPESSFQKL APSEYRYTLL RDRDEL 406 |
Gene Ontology | GO:0009986; C:cell surface; IDA:MGI. GO:0005788; C:endoplasmic reticulum lumen; IDA:UniProtKB. GO:0005789; C:endoplasmic reticulum membrane; IDA:UniProtKB. GO:0005793; C:endoplasmic reticulum-Golgi intermediate compartment; IDA:UniProtKB. GO:0003756; F:protein disulfide isomerase activity; IDA:UniProtKB. GO:0045454; P:cell redox homeostasis; TAS:UniProtKB. GO:0009100; P:glycoprotein metabolic process; IDA:UniProtKB. GO:0006986; P:response to unfolded protein; IDA:UniProtKB. |
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