CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-005459
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Rhombotin-2 
Protein Synonyms/Alias
 Cysteine-rich protein TTG-2; LIM domain only protein 2; LMO-2; T-cell translocation protein 2 
Gene Name
 LMO2 
Gene Synonyms/Alias
 RBTN2; RBTNL1; RHOM2; TTG2 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
143VGRRLYYKLGRKLCRubiquitination[1]
Reference
 [1] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 
Functional Description
 Acts with TAL1/SCL to regulate red blood cell development. Also acts with LDB1 to maintain erythroid precursors in an immature state. 
Sequence Annotation
 DOMAIN 30 89 LIM zinc-binding 1.
 DOMAIN 94 153 LIM zinc-binding 2.  
Keyword
 3D-structure; Alternative splicing; Chromosomal rearrangement; Complete proteome; LIM domain; Metal-binding; Nucleus; Proto-oncogene; Reference proteome; Repeat; Zinc. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 158 AA 
Protein Sequence
MEGSAVTVLE RGGASSPAER RSKRRRRSGG DGGGGGGARA PEGVRAPAAG QPRATKGAPP 60
PPGTPPPSPM SSAIERKSLD PSEEPVDEVL QIPPSLLTCG GCQQNIGDRY FLKAIDQYWH 120
EDCLSCDLCG CRLGEVGRRL YYKLGRKLCR RDYLRLFGQD GLCASCDKRI RAYEMTMRVK 180
DKVYHLECFK CAACQKHFCV GDRYLLINSD IVCEQDIYEW TKINGMI 227 
Gene Ontology
 GO:0005667; C:transcription factor complex; IDA:BHF-UCL.
 GO:0003682; F:chromatin binding; IEA:Compara.
 GO:0048037; F:cofactor binding; IPI:BHF-UCL.
 GO:0070888; F:E-box binding; IDA:BHF-UCL.
 GO:0000977; F:RNA polymerase II regulatory region sequence-specific DNA binding; IDA:BHF-UCL.
 GO:0001190; F:RNA polymerase II transcription factor binding transcription factor activity involved in positive regulation of transcription; IDA:BHF-UCL.
 GO:0001228; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription; IDA:BHF-UCL.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0097067; P:cellular response to thyroid hormone stimulus; IDA:UniProtKB.
 GO:0035162; P:embryonic hemopoiesis; IEA:Compara.
 GO:0042789; P:mRNA transcription from RNA polymerase II promoter; IDA:BHF-UCL.
 GO:0007275; P:multicellular organismal development; TAS:ProtInc.
 GO:0045647; P:negative regulation of erythrocyte differentiation; IEA:Compara. 
Interpro
 IPR001781; Znf_LIM. 
Pfam
 PF00412; LIM 
SMART
 SM00132; LIM 
PROSITE
 PS00478; LIM_DOMAIN_1
 PS50023; LIM_DOMAIN_2 
PRINTS