UniProt Accession

 ST17A_HUMAN; Q9UEE5; A4D1V6; Q8IVC8 

Genbank Protein ID

 AB011420; CH236951; AC005189; AC011738; AC093645; CH471073; BC023508; BC047696 

Genbank Nucleotide ID

 BAA34126.1; EAL24008.1; EAW94162.1; AAH23508.2; AAH47696.1 

Protein Name

 Serine/threonine-protein kinase 17A 

Protein Synonyms/Alias

 DAP kinase-related apoptosis-inducing protein kinase 1 

Gene Name

 STK17A 

Gene Synonyms/Alias

 DRAK1 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
90	SGKEFAAKFMRKRRK	ubiquitination	[1]
188	DVVHLDLKPQNILLT	ubiquitination	[1, 2, 3]
304	FIRTLLVKKPEDRAT	ubiquitination	[1]
317	ATAEECLKHPWLTQS	ubiquitination	[1]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [3] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094] 

Functional Description

 Acts as a positive regulator of apoptosis. Also acts as a regulator of cellular reactive oxygen species. 

Sequence Annotation

 DOMAIN 61 321 Protein kinase.
 NP_BIND 67 75 ATP (By similarity).
 ACT_SITE 186 186 Proton acceptor (By similarity).
 BINDING 90 90 ATP.
 MOD_RES 9 9 Phosphoserine.  

Keyword

 Apoptosis; ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; Serine/threonine-protein kinase; Transferase. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 414 AA 

Protein Sequence

Gene Ontology

 GO:0005634; C:nucleus; IDA:UniProtKB.
 GO:0005524; F:ATP binding; IDA:UniProtKB.
 GO:0004674; F:protein serine/threonine kinase activity; IDA:UniProtKB.
 GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
 GO:0006917; P:induction of apoptosis; IMP:UniProtKB.
 GO:0007243; P:intracellular protein kinase cascade; IDA:UniProtKB.
 GO:2000377; P:regulation of reactive oxygen species metabolic process; IMP:UniProtKB. 

Interpro

 IPR011009; Kinase-like_dom.
 IPR000719; Prot_kinase_cat_dom.
 IPR017441; Protein_kinase_ATP_BS.
 IPR002290; Ser/Thr_dual-sp_kinase_dom.
 IPR008271; Ser/Thr_kinase_AS. 

Pfam

 PF00069; Pkinase 

SMART

 SM00220; S_TKc 

PROSITE

 PS00107; PROTEIN_KINASE_ATP
 PS50011; PROTEIN_KINASE_DOM
 PS00108; PROTEIN_KINASE_ST 

PRINTS