| Tag | Content |
|---|
| CPLM ID | CPLM-016956 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Palmitoyltransferase ZDHHC17 |
Protein Synonyms/Alias | Huntingtin yeast partner H; Huntingtin-interacting protein 14; HIP-14; Huntingtin-interacting protein 3; HIP-3; Huntingtin-interacting protein H; Putative MAPK-activating protein PM11; Putative NF-kappa-B-activating protein 205; Zinc finger DHHC domain-containing protein 17; DHHC-17 |
Gene Name | ZDHHC17 |
Gene Synonyms/Alias | HIP14; HIP3; HYPH; KIAA0946; HSPC294 |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 50 | YGEPLGRKTHIDDYS | ubiquitination | [1, 2] |
|
Reference | [1] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA. Mol Cell Proteomics. 2012 May;11(5):148-59. [ PMID: 22505724] [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments. Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA. Mol Cell Proteomics. 2013 Mar;12(3):825-31. [ PMID: 23266961] |
Functional Description | Palmitoyltransferase specific for a subset of neuronal proteins, including SNAP25, DLG4/PSD95, GAD2, SYT1 and HD. Palmitoylates MPP1 in erythrocytes. May be involved in the sorting or targeting of critical proteins involved in the initiating events of endocytosis at the plasma membrane. Has transforming activity. Mediates Mg(2+) transport. |
Sequence Annotation | REPEAT 89 118 ANK 1.
REPEAT 123 155 ANK 2.
REPEAT 156 188 ANK 3.
REPEAT 189 219 ANK 4.
REPEAT 224 253 ANK 5.
ZN_FING 437 487 DHHC-type.
ACT_SITE 467 467 S-palmitoyl cysteine intermediate
MOD_RES 70 70 Phosphotyrosine (By similarity). |
Keyword | 3D-structure; Acyltransferase; Alternative splicing; ANK repeat; Complete proteome; Cytoplasmic vesicle; Golgi apparatus; Ion transport; Lipoprotein; Magnesium; Membrane; Metal-binding; Palmitate; Phosphoprotein; Polymorphism; Reference proteome; Repeat; Transferase; Transmembrane; Transmembrane helix; Transport; Tumor suppressor; Zinc; Zinc-finger. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 632 AA |
Protein Sequence | MQREEGFNTK MADGPDEYDT EAGCVPLLHP EEIKPQSHYN HGYGEPLGRK THIDDYSTWD 60
IVKATQYGIY ERCRELVEAG YDVRQPDKEN VTLLHWAAIN NRIDLVKYYI SKGAIVDQLG 120
GDLNSTPLHW ATRQGHLSMV VQLMKYGADP SLIDGEGCSC IHLAAQFGHT SIVAYLIAKG 180
QDVDMMDQNG MTPLMWAAYR THSVDPTRLL LTFNVSVNLG DKYHKNTALH WAVLAGNTTV 240
ISLLLEAGAN VDAQNIKGES ALDLAKQRKN VWMINHLQEA RQAKGYDNPS FLRKLKADKE 300
FRQKVMLGTP FLVIWLVGFI ADLNIDSWLI KGLMYGGVWA TVQFLSKSFF DHSMHSALPL 360
GIYLATKFWM YVTWFFWFWN DLNFLFIHLP FLANSVALFY NFGKSWKSDP GIIKATEEQK 420
KKTIVELAET GSLDLSIFCS TCLIRKPVRS KHCGVCNRCI AKFDHHCPWV GNCVGAGNHR 480
YFMGYLFFLL FMICWMIYGC ISYWGLHCET TYTKDGFWTY ITQIATCSPW MFWMFLNSVF 540
HFMWVAVLLM CQMYQISCLG ITTNERMNAR RYKHFKVTTT SIESPFNHGC VRNIIDFFEF 600
RCCGLFRPVI VDWTRQYTIE YDQISGSGYQ LV 632 |
Gene Ontology | GO:0030660; C:Golgi-associated vesicle membrane; IDA:UniProtKB. GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. GO:0015095; F:magnesium ion transmembrane transporter activity; IDA:UniProtKB. GO:0019706; F:protein-cysteine S-palmitoleyltransferase activity; IDA:UniProtKB. GO:0004871; F:signal transducer activity; IMP:UniProtKB. GO:0008270; F:zinc ion binding; IEA:InterPro. GO:0042953; P:lipoprotein transport; IDA:UniProtKB. GO:0043123; P:positive regulation of I-kappaB kinase/NF-kappaB cascade; IMP:UniProtKB. GO:0018345; P:protein palmitoylation; IEA:Compara. |
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