| Tag | Content |
|---|
| CPLM ID | CPLM-016425 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | CCR4-NOT transcription complex subunit 10 |
Protein Synonyms/Alias | |
Gene Name | Cnot10 |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 256 | SAPSLFLKSNFEYLR | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Is not required for association of CNOT7 to the CCR4- NOT complex (By similarity). |
Sequence Annotation | MOD_RES 2 2 N-acetylalanine (By similarity). |
Keyword | Acetylation; Alternative splicing; Coiled coil; Complete proteome; Cytoplasm; Nucleus; Reference proteome; RNA-mediated gene silencing; Transcription; Transcription regulation; Translation regulation. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 744 AA |
Protein Sequence | MAADKPADQG AEKHEGAGQS SGVTDQEKEL SASALQAFTS GNYDACLQHL ACLQDINKDD 60
YKIILNTAVA EFFKNNQTTT DNLRQTLNQL KNQVHSAVEE MDGLDDVENS MLYYNQAVIL 120
YHLRQYTEAI SVGEKLYQFI EPFEEKFAQA VCFLLVDLYI LTHQAEKALH LLAVLEKMIS 180
QGSGGKNGKN ETGNNSSKDG SNPKAESAAL IEAAKSKIHQ YKVRGYIQMK SLKACKREIK 240
SVMNTAGNSA PSLFLKSNFE YLRGNYRKAV KLLNSSNIAE HPGFMKTGEC LRCMFWNNLG 300
CIHFAMSKHN LGIFYFKKAL QENDNVCAQL SAGGTDPGKK FSGRPMCTLL TNKRYELLYN 360
CGIQLLHVGR PLAAFECLIE AVQVYHANPR LWLRLAECCI AANKGTSEQE TKGLPTKKGI 420
VQSIVGQGYH RKIVLASQSI QNTVYNDGQS SAIPVASVEF AAICLRNALL LLPEEQQDPK 480
QENGSKSSSQ LGGNTESSES SETCSSKSHD GDKFIPAPPS SPLRKQELEN LKCSILACSA 540
YVALALGDNL MALNHADQLL QQPKLSGSLK FLGHLYAAEA LISLDRISDA ITHLNPENVT 600
DVSLGISSNE QDQGSDKGEN EAMESSGKRA PQCYPSSVNS ARTVMLFNLG SAYCLRSEYD 660
KARKCLHQAA SMIHPKEVPP EAILLAVYLE LQNGNTQLAL QMIKRNQLLP AVKAHSDVRK 720
KTVFQPVHPI QPIQMPAFTT VQRK 744 |
Gene Ontology | GO:0030014; C:CCR4-NOT complex; ISS:UniProtKB. GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. GO:0031047; P:gene silencing by RNA; IEA:UniProtKB-KW. GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW. GO:0006417; P:regulation of translation; IEA:UniProtKB-KW. GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |