UniProt Accession

 PLSL_MOUSE; Q61233; Q3UE24; Q8R1X3; Q9CV77 

Genbank Protein ID

 D37837; AK009211; AK030806; AK030987; AK030996; AK088202; AK149790; AK151155; AK152891; AK153082; AK153206; AK169728; AK169833; BC022943 

Genbank Nucleotide ID

 BAA07085.1; BAB26141.1; BAE20456.1; BAC27205.1; BAC27208.1; BAC40207.1; BAE29087.1; BAE30161.1; BAE31574.1; BAE31707.1; BAE31806.1; BAE41332.1; BAE41398.1; AAH22943.1 

Protein Name

 Plastin-2 

Protein Synonyms/Alias

 65 kDa macrophage protein; L-plastin; Lymphocyte cytosolic protein 1; LCP-1; pp65 

Gene Name

 Lcp1 

Gene Synonyms/Alias

 Pls2 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
263	ESLEDLMKLSPEELL	ubiquitination	[1]
297	STDIKDSKAYYHLLE	ubiquitination	[1]
530	NWVNTTLKEAQKSSS	ubiquitination	[1]
584	EEKLNNAKYAISMAR	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Actin-binding protein. Plays a role in the activation of T-cells in response to costimulation through TCR/CD3 and CD2 or CD28. Modulates the cell surface expression of IL2RA/CD25 and CD69 (By similarity). 

Sequence Annotation

 DOMAIN 9 44 EF-hand 1.
 DOMAIN 49 84 EF-hand 2.
 DOMAIN 106 379 Actin-binding 1.
 DOMAIN 120 236 CH 1.
 DOMAIN 264 375 CH 2.
 DOMAIN 380 624 Actin-binding 2.
 DOMAIN 394 503 CH 3.
 DOMAIN 515 624 CH 4.
 MOD_RES 2 2 N-acetylalanine (By similarity).
 MOD_RES 5 5 Phosphoserine.
 MOD_RES 7 7 Phosphoserine.
 MOD_RES 28 28 Phosphotyrosine (By similarity).
 MOD_RES 30 30 Phosphoserine (By similarity).
 MOD_RES 76 76 N6-acetyllysine (By similarity).
 MOD_RES 88 88 N6-acetyllysine (By similarity).
 MOD_RES 124 124 Phosphotyrosine (By similarity).
 MOD_RES 257 257 Phosphoserine (By similarity).
 MOD_RES 294 294 N6-acetyllysine (By similarity).
 MOD_RES 297 297 N6-acetyllysine (By similarity).
 MOD_RES 323 323 Phosphoserine (By similarity).
 MOD_RES 361 361 N6-acetyllysine (By similarity).
 MOD_RES 472 472 N6-acetyllysine (By similarity).
 MOD_RES 542 542 N6-acetyllysine (By similarity).
 MOD_RES 579 579 N6-acetyllysine (By similarity).  

Keyword

 Acetylation; Actin-binding; Calcium; Cell junction; Cell membrane; Cell projection; Complete proteome; Cytoplasm; Cytoskeleton; Direct protein sequencing; Membrane; Metal-binding; Phosphoprotein; Reference proteome; Repeat. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 627 AA 

Protein Sequence

Gene Ontology

 GO:0005884; C:actin filament; IDA:MGI.
 GO:0030054; C:cell junction; IEA:UniProtKB-SubCell.
 GO:0005829; C:cytosol; ISS:UniProtKB.
 GO:0001891; C:phagocytic cup; IDA:MGI.
 GO:0001726; C:ruffle; IDA:MGI.
 GO:0032587; C:ruffle membrane; IEA:UniProtKB-SubCell.
 GO:0051015; F:actin filament binding; IDA:MGI.
 GO:0005509; F:calcium ion binding; IEA:InterPro.
 GO:0051017; P:actin filament bundle assembly; IDA:MGI.
 GO:0031100; P:organ regeneration; IEA:Compara.
 GO:0033157; P:regulation of intracellular protein transport; ISS:UniProtKB.
 GO:0002286; P:T cell activation involved in immune response; ISS:UniProtKB. 

Interpro

 IPR001589; Actinin_actin-bd_CS.
 IPR001715; CH-domain.
 IPR011992; EF-hand-like_dom.
 IPR018247; EF_Hand_1_Ca_BS.
 IPR002048; EF_hand_dom. 

Pfam

 PF00307; CH
 PF13499; EF_hand_5 

SMART

 SM00033; CH
 SM00054; EFh 

PROSITE

 PS00019; ACTININ_1
 PS00020; ACTININ_2
 PS50021; CH
 PS00018; EF_HAND_1
 PS50222; EF_HAND_2 

PRINTS