UniProt Accession

 TADA3_RAT; Q4V8F5 

Genbank Protein ID

 BC097414 

Genbank Nucleotide ID

 AAH97414.1 

Protein Name

 Transcriptional adapter 3 

Protein Synonyms/Alias

 ADA3 homolog; Transcriptional adapter 3-like; ADA3-like protein 

Gene Name

 Tada3 

Gene Synonyms/Alias

 Ada3; Tada3l 

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
418	KEKDQAWKTLKERES	acetylation	[1]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 

Functional Description

 Functions as a component of the PCAF complex. The PCAF complex is capable of efficiently acetylating histones in a nucleosomal context. The PCAF complex could be considered as the human version of the yeast SAGA complex. Also known as a coactivator for p53/TP53-dependent transcriptional activation (By similarity). Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4 (By similarity). 

Sequence Annotation

 MOD_RES 418 418 N6-acetyllysine (By similarity).  

Keyword

 Acetylation; Coiled coil; Complete proteome; Nucleus; Reference proteome; Transcription; Transcription regulation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 432 AA 

Protein Sequence

Gene Ontology

 GO:0005671; C:Ada2/Gcn5/Ada3 transcription activator complex; IEA:Compara.
 GO:0072686; C:mitotic spindle; IEA:Compara.
 GO:0030914; C:STAGA complex; IEA:Compara.
 GO:0033276; C:transcription factor TFTC complex; IEA:Compara.
 GO:0004402; F:histone acetyltransferase activity; IEA:Compara.
 GO:0030374; F:ligand-dependent nuclear receptor transcription coactivator activity; IEA:Compara.
 GO:0043966; P:histone H3 acetylation; IEA:Compara.
 GO:0007067; P:mitosis; IEA:Compara.
 GO:0045893; P:positive regulation of transcription, DNA-dependent; IEA:Compara.
 GO:0031063; P:regulation of histone deacetylation; IEA:Compara.
 GO:0001932; P:regulation of protein phosphorylation; IEA:Compara.
 GO:0031647; P:regulation of protein stability; IEA:Compara.
 GO:0090043; P:regulation of tubulin deacetylation; IEA:Compara.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 

Interpro

 IPR019340; Histone_AcTrfase_su3. 

Pfam

 PF10198; Ada3 

SMART

  

PROSITE

  

PRINTS