UniProt Accession

 D3YWW3_MOUSE; D3YWW3 

Genbank Protein ID

 AC144818 

Genbank Nucleotide ID

  

Protein Name

 Fascin 

Protein Synonyms/Alias

  

Gene Name

 Fscn1 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
35	AFRTHTGKYWTLTAT	acetylation	[1]
121	HGFIGCRKVTGTLDA	acetylation	[2]
121	HGFIGCRKVTGTLDA	succinylation	[2]
121	HGFIGCRKVTGTLDA	ubiquitination	[3]

Reference

 [1] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [2] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337]
 [3] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

  

Sequence Annotation

  

Keyword

 Complete proteome; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 144 AA 

Protein Sequence

Gene Ontology

 GO:0030175; C:filopodium; IDA:MGI.
 GO:0071437; C:invadopodium; IEA:Compara.
 GO:0001725; C:stress fiber; IEA:Compara.
 GO:0051015; F:actin filament binding; IMP:MGI.
 GO:0051017; P:actin filament bundle assembly; IDA:MGI.
 GO:0048870; P:cell motility; IEA:Compara. 

Interpro

 IPR008999; Actin_cross-linking.
 IPR010431; Fascin.
 IPR022768; Fascin-domain. 

Pfam

 PF06268; Fascin 

SMART

  

PROSITE

  

PRINTS