CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-032191
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 SH3 and PX domain-containing protein 2A 
Protein Synonyms/Alias
 cDNA FLJ57808, highly similar to Homo sapiens SH3 multiple domains 1 (SH3MD1), mRNA 
Gene Name
 SH3PXD2A 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
149QPYTSQSKDEIGFEKubiquitination[1, 2]
774EQPDPSGKELDTVPAubiquitination[2]
985CQILDGVKPFKGWVPubiquitination[2]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome; SH3 domain. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1000 AA 
Protein Sequence
MNGSFLLRLL FPVASILPET VLLRGADATA EPMILEQYVV VSNYKKQENS ELSLQAGEVV 60
DVIEKNESGW WFVSTSEEQG WVPATYLEAQ NGTRDDSDIN TSKTGEVSKR RKAHLRRLDR 120
RWTLGGMVNR QHSREEKYVT VQPYTSQSKD EIGFEKGVTV EVIRKNLEGW WYIRYLGKEG 180
WAPASYLKKA KDDLPTRKKN LAGPVEIIGN IMEISNLLNK KASGDKETPP AEGEGHEAPI 240
AKKEISLPIL CNASNGSAVG VPDRTVSRLA QGSPAVARIA PQRAQISSPN LRTRPPPRRE 300
SSLGFQLPKP PEPPSVEVEY YTIAEFQSCI SDGISFRGGQ KAEVIDKNSG GWWYVQIGEK 360
EGWAPASYID KRKKPNLSRR TSTLTRPKVP PPAPPSKPKE AEEGPTGASE SQDSPRKLKY 420
EEPEYDIPAF GFDSEPELSE EPVEDRASGE RRPAQPHRPS PASSLQRARF KVGESSEDVA 480
LEEETIYENE GFRPYAEDTL SARGSSGDSD SPGSSSLSLT RKNSPKSGSP KSSSLLKLKA 540
EKNAQAEMGK NHSSASFSSS ITINTTCCSS SSSSSSSLSK TSGDLKPRSA SDAGIRGTPK 600
VRAKKDADAN AGLTSCPRAK PSVRPKPFLN RAESQSQEKM DISTLRRQLR PTGQLRGGLK 660
GSKSEDSELP PQTASEAPSE GSRRSSSDLI TLPATTPPCP TKKEWEGPAT SYMTCSAYQK 720
VQDSEISFPA GVEVQVLEKQ ESGWWYVRFG ELEGWAPSHY LVLDENEQPD PSGKELDTVP 780
AKGRQNEGKS DSLEKIERRV QALNTVNQSK KATPPIPSKP PGGFGKTSGT PAVKMRNGVR 840
QVAVRPQSVF VSPPPKDNNL SCALRRNESL TATDGLRGVR RNSSFSTARS AAAEAKGRLA 900
ERAASQGSDS PLLPAQRNSI PVSPVRPKPI EKSQFIHNNL KDVYVSIADY EGDEETAGFQ 960
EGVSMEVLER NPNGWWYCQI LDGVKPFKGW VPSNYLEKKN 1000 
Gene Ontology
  
Interpro
 IPR011511; SH3_2.
 IPR001452; SH3_domain. 
Pfam
 PF00018; SH3_1
 PF07653; SH3_2 
SMART
 SM00326; SH3 
PROSITE
 PS50002; SH3 
PRINTS