CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-041845
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Sodium/calcium exchanger 1 
Protein Synonyms/Alias
 Solute carrier family 8 (Sodium/calcium exchanger), member 1, isoform CRA_f 
Gene Name
 Slc8a1 
Gene Synonyms/Alias
 mCG_140710 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
257DRRLLFYKYVYKRYRubiquitination[1]
283EGDRPASKTEIEMDGubiquitination[1]
356QVLSQQQKSRAFYRIubiquitination[1]
377TGAGNILKRHAADQAubiquitination[1]
572GNVIIPYKTIEGTARubiquitination[1]
606IVKTISVKVIDDEEYubiquitination[1]
615IDDEEYEKNKTFFIEubiquitination[1]
634RLVEMSEKKALLLNEubiquitination[1]
682ISEEYDDKQPLTSKEubiquitination[1]
729TVDKLIKKTNLALVVubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Membrane; Reference proteome; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 970 AA 
Protein Sequence
MLRLSLPPNV SMGFRLVALV ALLFSHVDHI TADTEAETGG NETTECTGSY YCKKGVILPI 60
WEPQDPSFGD KIARATVYFV AMVYMFLGVS IIADRFMSSI EVITSQEKEI TIKKPNGETT 120
KTTVRIWNET VSNLTLMALG SSAPEILLSV IEVCGHNFTA GDLGPSTIVG SAAFNMFIII 180
ALCVYVVPDG ETRKIKHLRV FFVTAAWSIF AYTWLYIILS VSSPGVVEVW EGLLTFFFFP 240
ICVVFAWVAD RRLLFYKYVY KRYRAGKQRG MIIEHEGDRP ASKTEIEMDG KVVNSHVDNF 300
LDGALVLEVD ERDQDDEEAR REMARILKEL KQKHPEKEIE QLIELANYQV LSQQQKSRAF 360
YRIQATRLMT GAGNILKRHA ADQARKAVSM HEVNMEMAEN DPVSKIFFEQ GTYQCLENCG 420
TVALTIMRRG GDLSTTVFVD FRTEDGTANA GSDYEFTEGT VIFKPGETQK EIRVGIIDDD 480
IFEEDENFLV HLSNVRVSSD VSEDGILESN HASSIACLGS PSTATITIFD DDHAGIFTFE 540
EPVTHVSESI GIMEVKVLRT SGARGNVIIP YKTIEGTARG GGEDFEDTCG ELEFQNDEIV 600
KTISVKVIDD EEYEKNKTFF IEIGEPRLVE MSEKKALLLN ELGGFTLTGK EMYGQPIFRK 660
VHARDHPIPS TVITISEEYD DKQPLTSKEE EERRIAEMGR PILGEHTKLE VIIEESYEFK 720
STVDKLIKKT NLALVVGTNS WREQFIEAIT VSAGEDDDDD ECGEEKLPSC FDYVMHFLTV 780
FWKVLFAFVP PTEYWNGWAC FIVSILMIGL LTAFIGDLAS HFGCTIGLKD SVTAVVFVAL 840
GTSVPDTFAS KVAATQDQYA DASIGNVTGS NAVNVFLGIG VAWSIAAIYH AANGEQFKVS 900
PGTLAFSVTL FTIFAFINVG VLLYRRRPEI GGELGGPRTA KLLTSSLFVL LWLLYIFFSS 960
LEAYCHIKGF 970 
Gene Ontology
 GO:0016323; C:basolateral plasma membrane; IDA:MGI.
 GO:0043197; C:dendritic spine; IEA:Compara.
 GO:0016021; C:integral to membrane; TAS:MGI.
 GO:0005887; C:integral to plasma membrane; IEA:Compara.
 GO:0014704; C:intercalated disc; IEA:Compara.
 GO:0005874; C:microtubule; IEA:Compara.
 GO:0005739; C:mitochondrion; IEA:Compara.
 GO:0030315; C:T-tubule; IDA:MGI.
 GO:0030018; C:Z disc; IEA:Compara.
 GO:0005432; F:calcium:sodium antiporter activity; IDA:MGI.
 GO:0070509; P:calcium ion import; IEA:Compara.
 GO:0060402; P:calcium ion transport into cytosol; IEA:Compara.
 GO:0055013; P:cardiac muscle cell development; IMP:MGI.
 GO:0060048; P:cardiac muscle contraction; IGI:MGI.
 GO:0086064; P:cell communication by electrical coupling involved in cardiac conduction; IEA:Compara.
 GO:0071320; P:cellular response to cAMP; IEA:Compara.
 GO:0034614; P:cellular response to reactive oxygen species; IEA:Compara.
 GO:0035050; P:embryonic heart tube development; IMP:MGI.
 GO:0001892; P:embryonic placenta development; IMP:MGI.
 GO:0003007; P:heart morphogenesis; IGI:MGI.
 GO:0048747; P:muscle fiber development; IGI:MGI.
 GO:0010763; P:positive regulation of fibroblast migration; IEA:Compara.
 GO:0009791; P:post-embryonic development; IGI:MGI.
 GO:0010881; P:regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion; IEA:Compara.
 GO:0002028; P:regulation of sodium ion transport; IEA:Compara.
 GO:0002026; P:regulation of the force of heart contraction; IMP:MGI.
 GO:0033198; P:response to ATP; IEA:Compara.
 GO:0042493; P:response to drug; IEA:Compara.
 GO:0009749; P:response to glucose stimulus; IEA:Compara.
 GO:0042542; P:response to hydrogen peroxide; IEA:Compara.
 GO:0001666; P:response to hypoxia; IEA:Compara.
 GO:0007584; P:response to nutrient; IEA:Compara.
 GO:0071436; P:sodium ion export; IEA:Compara.
 GO:0021537; P:telencephalon development; IEA:Compara. 
Interpro
 IPR003644; Calx_beta.
 IPR001623; DnaJ_domain.
 IPR004836; Na_Ca_Ex.
 IPR002987; NaCa_exhngr1.
 IPR004837; NaCa_Exmemb. 
Pfam
 PF03160; Calx-beta
 PF01699; Na_Ca_ex 
SMART
 SM00237; Calx_beta 
PROSITE
 PS50076; DNAJ_2 
PRINTS
 PR01259; NACAEXCHNGR.
 PR01260; NACAEXCHNGR1.