CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-010938
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Tyrosine-protein phosphatase YVH1 
Protein Synonyms/Alias
 PTPase YVH1 
Gene Name
 YVH1 
Gene Synonyms/Alias
 YIR026C 
Created Date
 July 27, 2013 
Organism
 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 
NCBI Taxa ID
 559292 
Lysine Modification
Position
Peptide
Type
References
361MVNFESEKVNR****ubiquitination[1]
Reference
 [1] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301] 
Functional Description
 May be directly involved in signal transduction and/or cell cycle regulation. It is necessary for maintaining growth rate or spore germination. Could show both activity toward tyrosine- protein phosphate as well as with serine-protein phosphate. 
Sequence Annotation
 DOMAIN 1 172 Tyrosine-protein phosphatase.
 ACT_SITE 117 117 Phosphocysteine intermediate (By
 MOD_RES 196 196 Phosphoserine.  
Keyword
 Complete proteome; Hydrolase; Phosphoprotein; Protein phosphatase; Reference proteome; Stress response. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 364 AA 
Protein Sequence
MAGNANSVDE EVTRILGGIY LGGIRPIIDH RPLGAEFNIT HILSVIKFQV IPEYLIRKGY 60
TLKNIPIDDD DVTDVLQYFD ETNRFIDQCL FPNEVEYSPR LVDFKKKPQR GAVFAHCQAG 120
LSRSVTFIVA YLMYRYGLSL SMAMHAVKRK KPSVEPNENF MEQLHLFEKM GGDFVDFDNP 180
AYKQWKLKQS IKLDPSGSEL VSNSGMFKDS ESSQDLDKLT EAEKSKVTAV RCKKCRTKLA 240
LSTSFIAHDP PSKESSEGHF IKRAANSHRI IDIQESQANC SHFFIEPLKW MQPELQGKQE 300
LEGKFSCPGC SSKVGGYNWK GSRCSCGKWV IPAIHLQTSK VDQFPLQSTA LPNMVNFESE 360
KVNR 364 
Gene Ontology
 GO:0005737; C:cytoplasm; IDA:SGD.
 GO:0005634; C:nucleus; IDA:SGD.
 GO:0004725; F:protein tyrosine phosphatase activity; IDA:SGD.
 GO:0008138; F:protein tyrosine/serine/threonine phosphatase activity; ISA:SGD.
 GO:0030476; P:ascospore wall assembly; IMP:SGD.
 GO:0019933; P:cAMP-mediated signaling; IMP:SGD.
 GO:0007126; P:meiosis; IMP:SGD.
 GO:0006950; P:response to stress; IEA:UniProtKB-KW.
 GO:0000027; P:ribosomal large subunit assembly; IMP:SGD. 
Interpro
 IPR000340; Dual-sp_phosphatase_cat-dom.
 IPR020422; Dual-sp_phosphatase_subgr_cat.
 IPR024950; DUSP.
 IPR016278; DUSP12.
 IPR000387; Tyr/Dual-sp_Pase. 
Pfam
 PF00782; DSPc 
SMART
 SM00195; DSPc 
PROSITE
 PS00383; TYR_PHOSPHATASE_1
 PS50056; TYR_PHOSPHATASE_2
 PS50054; TYR_PHOSPHATASE_DUAL 
PRINTS