CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-045403
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 ATP-dependent Clp protease proteolytic subunit 
Protein Synonyms/Alias
  
Gene Name
 CLPP 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
127NIYAKHTKQSLQVIEubiquitination[1, 2, 3]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [3] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Hydrolase; Protease; Reference proteome; Serine protease. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 190 AA 
Protein Sequence
MGPIDDSVAS LVIAQLLFLQ SESNKKPIHM YINSPGGVVT AGLAIYDTMQ YILNPICTWC 60
VGQAASMGSL LLAAGTPGMR HSLPNSRIMI HQPSGGARGQ ATDIAIQAEE IMKLKKQLYN 120
IYAKHTKQSL QVIESAMERD RYMSPMEAQE FGILDKVLVH PPQDGEDEPT LVQKEPVEAA 180
PAAEPVPAST 190 
Gene Ontology
 GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro.
 GO:0006508; P:proteolysis; IEA:UniProtKB-KW. 
Interpro
 IPR001907; ClpP.
 IPR023562; ClpP/TepA.
 IPR018215; ClpP_AS. 
Pfam
 PF00574; CLP_protease 
SMART
  
PROSITE
 PS00382; CLP_PROTEASE_HIS
 PS00381; CLP_PROTEASE_SER 
PRINTS
 PR00127; CLPPROTEASEP.