| Tag | Content |
|---|
| CPLM ID | CPLM-021286 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Protein-cysteine N-palmitoyltransferase porcupine |
Protein Synonyms/Alias | Protein MG61 |
Gene Name | PORCN |
Gene Synonyms/Alias | MG61; PORC; PPN |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 379 | LSACVLSKRCPPDCS | ubiquitination | [1] |
|
Reference | [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments. Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA. Mol Cell Proteomics. 2013 Mar;12(3):825-31. [ PMID: 23266961] |
Functional Description | protein-cysteine N-palmitoyltransferase that modulates the processing of Wnt proteins by mediating serine palmitoylation of Wnt family members. |
Sequence Annotation | ACT_SITE 341 341 Potential. |
Keyword | Acyltransferase; Alternative splicing; Complete proteome; Disease mutation; Endoplasmic reticulum; Membrane; Reference proteome; Transferase; Transmembrane; Transmembrane helix; Wnt signaling pathway. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 461 AA |
Protein Sequence | MATFSRQEFF QQLLQGCLLP TAQQGLDQIW LLLAICLACR LLWRLGLPSY LKHASTVAGG 60
FFSLYHFFQL HMVWVVLLSL LCYLVLFLCR HSSHRGVFLS VTILIYLLMG EMHMVDTVTW 120
HKMRGAQMIV AMKAVSLGFD LDRGEVGTVP SPVEFMGYLY FVGTIVFGPW ISFHSYLQAV 180
QGRPLSCRWL QKVARSLALA LLCLVLSTCV GPYLFPYFIP LNGDRLLRNK KRKARGTMVR 240
WLRAYESAVS FHFSNYFVGF LSEATATLAG AGFTEEKDHL EWDLTVSKPL NVELPRSMVE 300
VVTSWNLPMS YWLNNYVFKN ALRLGTFSAV LVTYAASALL HGFSFHLAAV LLSLAFITYV 360
EHVLRKRLAR ILSACVLSKR CPPDCSHQHR LGLGVRALNL LFGALAIFHL AYLGSLFDVD 420
VDDTTEEQGY GMAYTVHKWS ELSWASHWVT FGCWIFYRLI G 461 |
Gene Ontology | GO:0030176; C:integral to endoplasmic reticulum membrane; IEA:Compara. GO:0016746; F:transferase activity, transferring acyl groups; IEA:UniProtKB-KW. GO:0009100; P:glycoprotein metabolic process; IEA:Compara. GO:0016055; P:Wnt receptor signaling pathway; IEA:UniProtKB-KW. |
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Pfam | |
SMART | |
PROSITE | |
PRINTS | |