UniProt Accession

 TBB5_RAT; P69897; P05218; Q6P9X8; Q8WUC1; Q9CY33 

Genbank Protein ID

 AB011679; BX883048; BC060540 

Genbank Nucleotide ID

 BAA32736.1; CAE84031.1; AAH60540.1 

Protein Name

 Tubulin beta-5 chain 

Protein Synonyms/Alias

  

Gene Name

 Tubb5 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
58	YNEATGGKYVPRAIL	acetylation	[1]
58	YNEATGGKYVPRAIL	ubiquitination	[2]
252	QLNADLRKLAVNMVP	ubiquitination	[2]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405]
 [2] Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis.
 Na CH, Jones DR, Yang Y, Wang X, Xu Y, Peng J.
 J Proteome Res. 2012 Sep 7;11(9):4722-32. [PMID: 22871113] 

Functional Description

 Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. 

Sequence Annotation

 NP_BIND 140 146 GTP (Potential).
 MOD_RES 36 36 Phosphotyrosine (By similarity).
 MOD_RES 58 58 N6-acetyllysine; alternate (By
 MOD_RES 172 172 Phosphoserine; by CDK1 (By similarity).
 MOD_RES 318 318 Omega-N-methylarginine (By similarity).
 MOD_RES 340 340 Phosphotyrosine (By similarity).
 MOD_RES 382 382 Phosphoserine (By similarity).
 CROSSLNK 58 58 Glycyl lysine isopeptide (Lys-Gly)
 CROSSLNK 324 324 Glycyl lysine isopeptide (Lys-Gly)  

Keyword

 Acetylation; Alternative splicing; Complete proteome; Cytoplasm; Cytoskeleton; Direct protein sequencing; GTP-binding; Isopeptide bond; Methylation; Microtubule; Nucleotide-binding; Phosphoprotein; Reference proteome; S-nitrosylation; Ubl conjugation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 444 AA 

Protein Sequence

Gene Ontology

 GO:0044297; C:cell body; IEA:Compara.
 GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
 GO:0070062; C:extracellular vesicular exosome; IEA:Compara.
 GO:0005874; C:microtubule; IEA:UniProtKB-KW.
 GO:0005641; C:nuclear envelope lumen; IEA:Compara.
 GO:0005886; C:plasma membrane; IEA:Compara.
 GO:0043234; C:protein complex; IDA:RGD.
 GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
 GO:0003924; F:GTPase activity; IEA:InterPro.
 GO:0032403; F:protein complex binding; IDA:RGD.
 GO:0005200; F:structural constituent of cytoskeleton; IEA:Compara.
 GO:0051258; P:protein polymerization; IEA:InterPro.
 GO:0051225; P:spindle assembly; IEA:Compara. 

Interpro

 IPR013838; Beta-tubulin_BS.
 IPR002453; Beta_tubulin.
 IPR008280; Tub_FtsZ_C.
 IPR000217; Tubulin.
 IPR018316; Tubulin/FtsZ_2-layer-sand-dom.
 IPR023123; Tubulin_C.
 IPR017975; Tubulin_CS.
 IPR003008; Tubulin_FtsZ_GTPase. 

Pfam

 PF00091; Tubulin
 PF03953; Tubulin_C 

SMART

 SM00864; Tubulin
 SM00865; Tubulin_C 

PROSITE

 PS00227; TUBULIN
 PS00228; TUBULIN_B_AUTOREG 

PRINTS

 PR01163; BETATUBULIN.
 PR01161; TUBULIN.