| Tag | Content |
|---|
| CPLM ID | CPLM-002910 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Cardiolipin synthase |
Protein Synonyms/Alias | CL synthase |
Gene Name | cls |
Gene Synonyms/Alias | nov; yciJ; b1249; JW1241 |
Created Date | July 27, 2013 |
Organism | Escherichia coli (strain K12) |
NCBI Taxa ID | 83333 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 80 | AMWPSTAKWLNDLKA | acetylation | [1] | | 89 | LNDLKACKHIFAEEN | acetylation | [1] | | 105 | SVAAPLFKLCERRQG | acetylation | [1] | | 249 | MVDPRYFKQDAGVGQ | acetylation | [1] | | 371 | VSIILPRKNDSMLVG | acetylation | [1] |
|
Reference | [1] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli. Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C. Mol Cell. 2013 Jul 25;51(2):265-72. [ PMID: 23830618] |
Functional Description | Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol. Affects resistance to the gyrase inhibitor novobiocin. |
Sequence Annotation | DOMAIN 219 246 PLD phosphodiesterase 1.
DOMAIN 399 426 PLD phosphodiesterase 2.
ACT_SITE 224 224 Potential.
ACT_SITE 226 226 Potential.
ACT_SITE 231 231 Potential.
ACT_SITE 404 404 Potential.
ACT_SITE 406 406 Potential.
ACT_SITE 411 411 Potential. |
Keyword | Cell inner membrane; Cell membrane; Complete proteome; Lipid biosynthesis; Lipid metabolism; Membrane; Phospholipid biosynthesis; Phospholipid metabolism; Reference proteome; Repeat; Transferase; Transmembrane; Transmembrane helix. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 486 AA |
Protein Sequence | MTTVYTLVSW LAILGYWLLI AGVTLRILMK RRAVPSAMAW LLIIYILPLV GIIAYLAVGE 60
LHLGKRRAER ARAMWPSTAK WLNDLKACKH IFAEENSSVA APLFKLCERR QGIAGVKGNQ 120
LQLMTESDDV MQALIRDIQL ARHNIEMVFY IWQPGGMADQ VAESLMAAAR RGIHCRLMLD 180
SAGSVAFFRS PWPELMRNAG IEVVEALKVN LMRVFLRRMD LRQHRKMIMI DNYIAYTGSM 240
NMVDPRYFKQ DAGVGQWIDL MARMEGPIAT AMGIIYSCDW EIETGKRILP PPPDVNIMPF 300
EQASGHTIHT IASGPGFPED LIHQALLTAA YSAREYLIMT TPYFVPSDDL LHAICTAAQR 360
GVDVSIILPR KNDSMLVGWA SRAFFTELLA AGVKIYQFEG GLLHTKSVLV DGELSLVGTV 420
NLDMRSLWLN FEITLAIDDK GFGADLAAVQ DDYISRSRLL DARLWLKRPL WQRVAERLFY 480
FFSPLL 486 |
Gene Ontology | GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. GO:0016020; C:membrane; IDA:EcoCyc. GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. GO:0008808; F:cardiolipin synthase activity; IDA:EcoCyc. GO:0032049; P:cardiolipin biosynthetic process; IMP:EcoCyc. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |