CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-012740
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Dual specificity protein phosphatase 6 
Protein Synonyms/Alias
 Dual specificity protein phosphatase PYST1; Mitogen-activated protein kinase phosphatase 3; MAP kinase phosphatase 3; MKP-3 
Gene Name
 DUSP6 
Gene Synonyms/Alias
 MKP3; PYST1 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
68IMLRRLQKGNLPVRAubiquitination[1]
254FENAGEFKYKQIPISubiquitination[1, 2]
324NDAYDIVKMKKSNISubiquitination[1, 2]
327YDIVKMKKSNISPNFubiquitination[1, 2]
Reference
 [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 
Functional Description
 Inactivates MAP kinases. Has a specificity for the ERK family. 
Sequence Annotation
 DOMAIN 30 148 Rhodanese.
 DOMAIN 206 381 Tyrosine-protein phosphatase.
 ACT_SITE 293 293 Phosphocysteine intermediate.
 MOD_RES 331 331 Phosphoserine (By similarity).  
Keyword
 3D-structure; Alternative splicing; Complete proteome; Cytoplasm; Hydrolase; Phosphoprotein; Polymorphism; Protein phosphatase; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 381 AA 
Protein Sequence
MIDTLRPVPF ASEMAISKTV AWLNEQLELG NERLLLMDCR PQELYESSHI ESAINVAIPG 60
IMLRRLQKGN LPVRALFTRG EDRDRFTRRC GTDTVVLYDE SSSDWNENTG GESVLGLLLK 120
KLKDEGCRAF YLEGGFSKFQ AEFSLHCETN LDGSCSSSSP PLPVLGLGGL RISSDSSSDI 180
ESDLDRDPNS ATDSDGSPLS NSQPSFPVEI LPFLYLGCAK DSTNLDVLEE FGIKYILNVT 240
PNLPNLFENA GEFKYKQIPI SDHWSQNLSQ FFPEAISFID EARGKNCGVL VHCLAGISRS 300
VTVTVAYLMQ KLNLSMNDAY DIVKMKKSNI SPNFNFMGQL LDFERTLGLS SPCDNRVPAQ 360
QLYFTTPSNQ NVYQVDSLQS T 381 
Gene Ontology
 GO:0005829; C:cytosol; IBA:RefGenome.
 GO:0005654; C:nucleoplasm; TAS:Reactome.
 GO:0017017; F:MAP kinase tyrosine/serine/threonine phosphatase activity; IDA:UniProtKB.
 GO:0004725; F:protein tyrosine phosphatase activity; IEA:EC.
 GO:0030154; P:cell differentiation; IEA:Compara.
 GO:0009953; P:dorsal/ventral pattern formation; IBA:RefGenome.
 GO:0045087; P:innate immune response; TAS:Reactome.
 GO:0002755; P:MyD88-dependent toll-like receptor signaling pathway; TAS:Reactome.
 GO:0070373; P:negative regulation of ERK1 and ERK2 cascade; IMP:UniProtKB.
 GO:0048011; P:neurotrophin TRK receptor signaling pathway; TAS:Reactome.
 GO:0035335; P:peptidyl-tyrosine dephosphorylation; IDA:UniProtKB.
 GO:0043065; P:positive regulation of apoptotic process; IDA:UniProtKB.
 GO:0042663; P:regulation of endodermal cell fate specification; IBA:RefGenome.
 GO:0040036; P:regulation of fibroblast growth factor receptor signaling pathway; IBA:RefGenome.
 GO:0060420; P:regulation of heart growth; IBA:RefGenome.
 GO:0042493; P:response to drug; IEA:Compara.
 GO:0051409; P:response to nitrosative stress; IEP:UniProtKB.
 GO:0014070; P:response to organic cyclic compound; IEA:Compara.
 GO:0051403; P:stress-activated MAPK cascade; TAS:Reactome.
 GO:0034166; P:toll-like receptor 10 signaling pathway; TAS:Reactome.
 GO:0034134; P:toll-like receptor 2 signaling pathway; TAS:Reactome.
 GO:0034138; P:toll-like receptor 3 signaling pathway; TAS:Reactome.
 GO:0034142; P:toll-like receptor 4 signaling pathway; TAS:Reactome.
 GO:0034146; P:toll-like receptor 5 signaling pathway; TAS:Reactome.
 GO:0034162; P:toll-like receptor 9 signaling pathway; TAS:Reactome.
 GO:0038123; P:toll-like receptor TLR1:TLR2 signaling pathway; TAS:Reactome.
 GO:0038124; P:toll-like receptor TLR6:TLR2 signaling pathway; TAS:Reactome.
 GO:0035666; P:TRIF-dependent toll-like receptor signaling pathway; TAS:Reactome. 
Interpro
 IPR000340; Dual-sp_phosphatase_cat-dom.
 IPR020422; Dual-sp_phosphatase_subgr_cat.
 IPR024950; DUSP.
 IPR008343; MKP.
 IPR001763; Rhodanese-like_dom.
 IPR000387; Tyr/Dual-sp_Pase. 
Pfam
 PF00782; DSPc
 PF00581; Rhodanese 
SMART
 SM00195; DSPc
 SM00450; RHOD 
PROSITE
 PS50206; RHODANESE_3
 PS00383; TYR_PHOSPHATASE_1
 PS50056; TYR_PHOSPHATASE_2
 PS50054; TYR_PHOSPHATASE_DUAL 
PRINTS
 PR01764; MAPKPHPHTASE.