UniProt Accession

 B4DPD5_HUMAN; B4DPD5 

Genbank Protein ID

 AK298287 

Genbank Nucleotide ID

 BAG60547.1 

Protein Name

 cDNA FLJ56307, highly similar to Ubiquitin thioesterase protein OTUB1 (EC 3.4.-.-) 

Protein Synonyms/Alias

  

Gene Name

  

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
96	LELSVLYKEYAEDDN	ubiquitination	[1]
108	DDNIYQQKIKDLHKK	ubiquitination	[1, 2, 3]
121	KKYSYIRKTRPDGNC	ubiquitination	[1, 2, 3]
146	EALLDDSKELQRFKA	ubiquitination	[1, 2, 3]
225	GYLQRESKFFEHFIE	ubiquitination	[2, 3]

Reference

 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965]
 [3] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 

Functional Description

  

Sequence Annotation

  

Keyword

  

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 308 AA 

Protein Sequence

Gene Ontology

 GO:0008242; F:omega peptidase activity; IEA:InterPro.
 GO:0019538; P:protein metabolic process; IEA:InterPro. 

Interpro

 IPR003323; OTU.
 IPR019400; Peptidase_C65_otubain.
 IPR016615; Ubiquitin_thioesterase_Otubain. 

Pfam

 PF10275; Peptidase_C65 

SMART

  

PROSITE

 PS50802; OTU 

PRINTS