UniProt Accession

 MQSA_ECOLI; Q46864; Q2M9H9 

Genbank Protein ID

 U28377; U00096; AP009048 

Genbank Nucleotide ID

 AAA69189.1; AAC76057.1; BAE77077.1 

Protein Name

 Antitoxin MqsA 

Protein Synonyms/Alias

  

Gene Name

 mqsA 

Gene Synonyms/Alias

 ygiT; b3021; JW2989 

Created Date

 July 27, 2013 

Organism

 Escherichia coli (strain K12) 

NCBI Taxa ID

 83333 

Lysine Modification

Position	Peptide	Type	References
122	KLLRVLDKHPELLNE	acetylation	[1]

Reference

 [1] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli.
 Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C.
 Mol Cell. 2013 Jul 25;51(2):265-72. [PMID: 23830618] 

Functional Description

 Antitoxin component of a toxin-antitoxin (TA) module. Labile antitoxin that binds to the MqsR mRNA interferase toxin and neutralizes its endoribonuclease activity. Overexpression prevents MqsR-mediated cessation of cell growth and inhibition of cell proliferation. Overexpression also increases biofilm formation, perhaps by repressing cspD. 

Sequence Annotation

 DOMAIN 74 127 HTH cro/C1-type.
 DNA_BIND 85 104 H-T-H motif (Potential).
 METAL 3 3 Zinc; structural.
 METAL 6 6 Zinc; structural.
 METAL 37 37 Zinc; structural.
 METAL 40 40 Zinc; structural.  

Keyword

 3D-structure; Complete proteome; DNA-binding; Metal-binding; Reference proteome; Transcription; Transcription regulation; Zinc. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 131 AA 

Protein Sequence

Gene Ontology

 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0043565; F:sequence-specific DNA binding; IDA:EcoCyc.
 GO:0006355; P:regulation of transcription, DNA-dependent; IMP:EcoCyc.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 

Interpro

 IPR001387; HTH.
 IPR010982; Lambda_DNA-bd_dom.
 IPR022452; Znf/HTH_YgiT.
 IPR022453; Znf_YgiT-type. 

Pfam

  

SMART

 SM00530; HTH_XRE 

PROSITE

 PS50943; HTH_CROC1 

PRINTS