UniProt Accession

 OLR1_HUMAN; P78380; A8K7V9; B4DI48; G3V1I4; Q2PP00; Q7Z484 

Genbank Protein ID

 AB010710; AF035776; AF079167; AF079166; AF079164; AF079165; AB102861; AJ131757; BX344276; AK292124; AK295409; DQ314885; AC024224; CH471094; CH471094; BC022295 

Genbank Nucleotide ID

 BAA24580.1; AAC82329.1; AAC97927.1; AAC97927.1; AAC97927.1; AAC97927.1; BAC81565.1; CAB38175.1; BAF84813.1; BAG58360.1; ABC40744.1; EAW96157.1; EAW96158.1; AAH22295.1 

Protein Name

 Oxidized low-density lipoprotein receptor 1 

Protein Synonyms/Alias

 Ox-LDL receptor 1; C-type lectin domain family 8 member A; Lectin-like oxidized LDL receptor 1; LOX-1; Lectin-like oxLDL receptor 1; hLOX-1; Lectin-type oxidized LDL receptor 1; Oxidized low-density lipoprotein receptor 1, soluble form 

Gene Name

 OLR1 

Gene Synonyms/Alias

 CLEC8A; LOX1 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
12	DLKIQTVKDQPDEKS	ubiquitination	[1]

Reference

 [1] Ubiquitin ligase substrate identification through quantitative proteomics at both the protein and peptide levels.
 Lee KA, Hammerle LP, Andrews PS, Stokes MP, Mustelin T, Silva JC, Black RA, Doedens JR.
 J Biol Chem. 2011 Dec 2;286(48):41530-8. [PMID: 21987572] 

Functional Description

 Receptor that mediates the recognition, internalization and degradation of oxidatively modified low density lipoprotein (oxLDL) by vascular endothelial cells. OxLDL is a marker of atherosclerosis that induces vascular endothelial cell activation and dysfunction, resulting in pro-inflammatory responses, pro- oxidative conditions and apoptosis. Its association with oxLDL induces the activation of NF-kappa-B through an increased production of intracellular reactive oxygen and a variety of pro- atherogenic cellular responses including a reduction of nitric oxide (NO) release, monocyte adhesion and apoptosis. In addition to binding oxLDL, it acts as a receptor for the HSP70 protein involved in antigen cross-presentation to naive T-cells in dendritic cells, thereby participating in cell-mediated antigen cross-presentation. Also involved in inflammatory process, by acting as a leukocyte-adhesion molecule at the vascular interface in endotoxin-induced inflammation. Also acts as a receptor for advanced glycation end (AGE) products, activated platelets, monocytes, apoptotic cells and both Gram-negative and Gram- positive bacteria. 

Sequence Annotation

 DOMAIN 151 265 C-type lectin.
 REGION 58 150 Neck.
 CARBOHYD 73 73 N-linked (GlcNAc...) (Potential).
 CARBOHYD 139 139 N-linked (GlcNAc...) (Complex).
 DISULFID 140 140 Interchain.
 DISULFID 144 155
 DISULFID 172 264
 DISULFID 243 256  

Keyword

 3D-structure; Alternative splicing; Cell adhesion; Cell membrane; Coiled coil; Complete proteome; Disulfide bond; Glycoprotein; Immunity; Inflammatory response; Lectin; Membrane; Polymorphism; Receptor; Reference proteome; Secreted; Signal-anchor; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 273 AA 

Protein Sequence

Gene Ontology

 GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
 GO:0005887; C:integral to plasma membrane; TAS:ProtInc.
 GO:0030246; F:carbohydrate binding; IEA:InterPro.
 GO:0005041; F:low-density lipoprotein receptor activity; IEA:Compara.
 GO:0008015; P:blood circulation; TAS:ProtInc.
 GO:0007596; P:blood coagulation; TAS:Reactome.
 GO:0008219; P:cell death; IEA:Compara.
 GO:0006954; P:inflammatory response; IEA:UniProtKB-KW.
 GO:0007159; P:leukocyte cell-cell adhesion; IEA:Compara.
 GO:0050900; P:leukocyte migration; TAS:Reactome.
 GO:0042157; P:lipoprotein metabolic process; IEA:Compara.
 GO:0006508; P:proteolysis; TAS:ProtInc.
 GO:0042542; P:response to hydrogen peroxide; IEA:Compara. 

Interpro

 IPR001304; C-type_lectin.
 IPR016186; C-type_lectin-like.
 IPR016187; C-type_lectin_fold. 

Pfam

 PF00059; Lectin_C 

SMART

 SM00034; CLECT 

PROSITE

 PS00615; C_TYPE_LECTIN_1
 PS50041; C_TYPE_LECTIN_2 

PRINTS