UniProt Accession

 KAP3_RAT; P12369 

Genbank Protein ID

 M12492 

Genbank Nucleotide ID

 AAA42047.1 

Protein Name

 cAMP-dependent protein kinase type II-beta regulatory subunit 

Protein Synonyms/Alias

  

Gene Name

 Prkar2b 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
174	AMFEKLVKEGEHVID	acetylation	[1]
174	AMFEKLVKEGEHVID	ubiquitination	[2]
285	LEVSERLKVVDVIGT	acetylation	[1]
357	ELALVTNKPRAASAH	ubiquitination	[2]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405]
 [2] Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis.
 Na CH, Jones DR, Yang Y, Wang X, Xu Y, Peng J.
 J Proteome Res. 2012 Sep 7;11(9):4722-32. [PMID: 22871113] 

Functional Description

 Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells. Type II regulatory chains mediate membrane association by binding to anchoring proteins, including the MAP2 kinase. 

Sequence Annotation

 NP_BIND 152 273 cAMP 1.
 NP_BIND 274 416 cAMP 2.
 REGION 2 151 Dimerization and phosphorylation.
 BINDING 221 221 cAMP 1.
 BINDING 230 230 cAMP 1.
 BINDING 350 350 cAMP 2.
 BINDING 359 359 cAMP 2.
 MOD_RES 2 2 N-acetylserine (Probable).
 MOD_RES 83 83 Phosphoserine (By similarity).
 MOD_RES 85 85 Phosphoserine (By similarity).
 MOD_RES 112 112 Phosphoserine.  

Keyword

 3D-structure; Acetylation; cAMP; cAMP-binding; Cell membrane; Complete proteome; Cytoplasm; Membrane; Nucleotide-binding; Phosphoprotein; Reference proteome; Repeat. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 416 AA 

Protein Sequence

Gene Ontology

 GO:0005952; C:cAMP-dependent protein kinase complex; IDA:RGD.
 GO:0005813; C:centrosome; IEA:Compara.
 GO:0045121; C:membrane raft; IDA:RGD.
 GO:0005743; C:mitochondrial inner membrane; IDA:RGD.
 GO:0048471; C:perinuclear region of cytoplasm; IDA:RGD.
 GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
 GO:0030552; F:cAMP binding; IDA:RGD.
 GO:0008603; F:cAMP-dependent protein kinase regulator activity; IDA:RGD.
 GO:0019904; F:protein domain specific binding; IMP:RGD.
 GO:0034236; F:protein kinase A catalytic subunit binding; IC:RGD.
 GO:0006631; P:fatty acid metabolic process; IEA:Compara.
 GO:0007612; P:learning; IEA:Compara.
 GO:0097332; P:response to antipsychotic drug; IEP:RGD.
 GO:0097338; P:response to clozapine; IEP:RGD.
 GO:0007165; P:signal transduction; IEA:InterPro. 

Interpro

 IPR002373; cAMP/cGMP_kin.
 IPR012198; cAMP_dep_PK_reg_su.
 IPR003117; cAMP_dep_PK_reg_su_I/II_a/b.
 IPR018490; cNMP-bd-like.
 IPR018488; cNMP-bd_CS.
 IPR000595; cNMP-bd_dom.
 IPR014710; RmlC-like_jellyroll. 

Pfam

 PF00027; cNMP_binding
 PF02197; RIIa 

SMART

 SM00100; cNMP
 SM00394; RIIa 

PROSITE

 PS00888; CNMP_BINDING_1
 PS00889; CNMP_BINDING_2
 PS50042; CNMP_BINDING_3 

PRINTS

 PR00103; CAMPKINASE.