CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-031175
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Vitamin D3 receptor 
Protein Synonyms/Alias
 cDNA FLJ51539, highly similar to Vitamin D3 receptor 
Gene Name
 VDR 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
270YRVSDVTKAGHSLELubiquitination[1, 2]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; DNA-binding; Metal-binding; Nucleus; Receptor; Reference proteome; Transcription; Transcription regulation; Zinc; Zinc-finger. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 395 AA 
Protein Sequence
MSMEHAALTA TGAGGSWRSM KRKALFTCPF NGDCRITKDN RRHCQACRLK RCVDIGMMKE 60
FILTDEEVQR KREMILKRKE EEALKDSLRP KLSEEQQRII AILLDAHHKT YDPTYSDFCQ 120
FRPPVRVNDG GGSHPSRPNS RHTPSFSGDS SSSCSDHCIT SSDMMDSSSF SNLDLSEEDS 180
DDPSVTLELS QLSMLPHLAD LVSYSIQKVI GFAKMIPGFR DLTSEDQIVL LKSSAIEVIM 240
LRSNESFTMD DMSWTCGNQD YKYRVSDVTK AGHSLELIEP LIKFQVGLKK LNLHEEEHVL 300
LMAICIVSPD RPGVQDAALI EAIQDRLSNT LQTYIRCRHP PPGSHLLYAK MIQKLADLRS 360
LNEEHSKQYR CLSFQPECSM KLTPLVLEVF GNEIS 395 
Gene Ontology
 GO:0005634; C:nucleus; IEA:UniProtKB-KW.
 GO:0008434; F:calcitriol receptor activity; IEA:InterPro.
 GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
 GO:0003707; F:steroid hormone receptor activity; IEA:InterPro.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0070561; P:vitamin D receptor signaling pathway; IEA:GOC. 
Interpro
 IPR008946; Nucl_hormone_rcpt_ligand-bd.
 IPR000536; Nucl_hrmn_rcpt_lig-bd_core.
 IPR001723; Str_hrmn_rcpt.
 IPR000324; VitD_rcpt.
 IPR001628; Znf_hrmn_rcpt.
 IPR013088; Znf_NHR/GATA. 
Pfam
 PF00104; Hormone_recep
 PF00105; zf-C4 
SMART
 SM00430; HOLI
 SM00399; ZnF_C4 
PROSITE
 PS51030; NUCLEAR_REC_DBD_2 
PRINTS
 PR00398; STRDHORMONER.
 PR00350; VITAMINDR.